Autoantibodies directed to centromere protein F in a patient with BRCA1 gene mutation

Fiona Moghaddas; Fredrick Joshua; Roberta Taylor; Marvin J. Fritzler; Ban Hock Toh

doi:10.1186/s13104-016-1908-7

Autoantibodies directed to centromere protein F in a patient with BRCA1 gene mutation

Fiona Moghaddas^*, Fredrick Joshua, Roberta Taylor, Marvin J. Fritzler, Ban Hock Toh

^*Corresponding author for this work

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Abstract

Background: Autoantibodies directed to centromere protein F were first reported in 1993 and their association with malignancy has been well documented. Case: We present the case of a 48-year-old Caucasian female with a BRCA1 gene mutation associated with bilateral breast cancer. Antinuclear autoantibody immunofluorescence performed for workup of possible inflammatory arthropathy showed a high titre cell cycle related nuclear speckled pattern, with subsequent confirmation by addressable laser bead immunoassay of the target antigen as an immunodominant epitope at the C-terminus of centromere protein F. Conclusion: Here we review the current literature on centromere protein F, its association with breast cancer and present the first case of this antibody being identified in a person with a BRCA1 gene mutation.

Original language	English
Article number	84
Pages (from-to)	1-4
Number of pages	4
Journal	BMC Research Notes
Volume	9
DOIs	https://doi.org/10.1186/s13104-016-1908-7
Publication status	Published - 11 Feb 2016
Externally published	Yes

Bibliographical note

Copyright the Author(s) 2016. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

ALBIA
antinuclear antibody
BRCA1
CENP-F
malignancy

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10.1186/s13104-016-1908-7Licence: CC BY

Publisher VersionFinal published version, 807 KBLicence: CC BY

Cite this

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title = "Autoantibodies directed to centromere protein F in a patient with BRCA1 gene mutation",

abstract = "Background: Autoantibodies directed to centromere protein F were first reported in 1993 and their association with malignancy has been well documented. Case: We present the case of a 48-year-old Caucasian female with a BRCA1 gene mutation associated with bilateral breast cancer. Antinuclear autoantibody immunofluorescence performed for workup of possible inflammatory arthropathy showed a high titre cell cycle related nuclear speckled pattern, with subsequent confirmation by addressable laser bead immunoassay of the target antigen as an immunodominant epitope at the C-terminus of centromere protein F. Conclusion: Here we review the current literature on centromere protein F, its association with breast cancer and present the first case of this antibody being identified in a person with a BRCA1 gene mutation.",

keywords = "ALBIA, antinuclear antibody, BRCA1, CENP-F, malignancy",

author = "Fiona Moghaddas and Fredrick Joshua and Roberta Taylor and Fritzler, \{Marvin J.\} and Toh, \{Ban Hock\}",

note = "Copyright the Author(s) 2016. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2016",

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day = "11",

doi = "10.1186/s13104-016-1908-7",

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TY - JOUR

T1 - Autoantibodies directed to centromere protein F in a patient with BRCA1 gene mutation

AU - Moghaddas, Fiona

AU - Joshua, Fredrick

AU - Taylor, Roberta

AU - Fritzler, Marvin J.

AU - Toh, Ban Hock

N1 - Copyright the Author(s) 2016. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2016/2/11

Y1 - 2016/2/11

N2 - Background: Autoantibodies directed to centromere protein F were first reported in 1993 and their association with malignancy has been well documented. Case: We present the case of a 48-year-old Caucasian female with a BRCA1 gene mutation associated with bilateral breast cancer. Antinuclear autoantibody immunofluorescence performed for workup of possible inflammatory arthropathy showed a high titre cell cycle related nuclear speckled pattern, with subsequent confirmation by addressable laser bead immunoassay of the target antigen as an immunodominant epitope at the C-terminus of centromere protein F. Conclusion: Here we review the current literature on centromere protein F, its association with breast cancer and present the first case of this antibody being identified in a person with a BRCA1 gene mutation.

AB - Background: Autoantibodies directed to centromere protein F were first reported in 1993 and their association with malignancy has been well documented. Case: We present the case of a 48-year-old Caucasian female with a BRCA1 gene mutation associated with bilateral breast cancer. Antinuclear autoantibody immunofluorescence performed for workup of possible inflammatory arthropathy showed a high titre cell cycle related nuclear speckled pattern, with subsequent confirmation by addressable laser bead immunoassay of the target antigen as an immunodominant epitope at the C-terminus of centromere protein F. Conclusion: Here we review the current literature on centromere protein F, its association with breast cancer and present the first case of this antibody being identified in a person with a BRCA1 gene mutation.

KW - ALBIA

KW - antinuclear antibody

KW - BRCA1

KW - CENP-F

KW - malignancy

UR - https://www.scopus.com/pages/publications/84957688906

U2 - 10.1186/s13104-016-1908-7

DO - 10.1186/s13104-016-1908-7

M3 - Article

C2 - 26868636

AN - SCOPUS:84957688906

SN - 1756-0500

VL - 9

SP - 1

EP - 4

JO - BMC Research Notes

JF - BMC Research Notes

M1 - 84

ER -

Autoantibodies directed to centromere protein F in a patient with BRCA1 gene mutation

Abstract

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Keywords

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