Autobiographical narratives relate to Alzheimer's disease biomarkers in older adults

Rachel F. Buckley; Michael M. Saling; Muireann Irish; David Ames; Christopher C. Rowe; Victor L. Villemagne; Nicola T. Lautenschlager; Paul Maruff; S. Lance Macaulay; Ralph N. Martins; Cassandra Szoeke; Colin L. Masters; Stephanie R. Rainey-Smith; Alan Rembach; Greg Savage; Kathryn A. Ellis

doi:10.1017/S1041610214001136

Autobiographical narratives relate to Alzheimer's disease biomarkers in older adults

Rachel F. Buckley^*, Michael M. Saling, Muireann Irish, David Ames, Christopher C. Rowe, Victor L. Villemagne, Nicola T. Lautenschlager, Paul Maruff, S. Lance Macaulay, Ralph N. Martins, Cassandra Szoeke, Colin L. Masters, Stephanie R. Rainey-Smith, Alan Rembach, Greg Savage, Kathryn A. Ellis

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Background: Autobiographical memory (ABM), personal semantic memory (PSM), and autonoetic consciousness are affected in individuals with mild cognitive impairment (MCI) but their relationship with Alzheimer's disease (AD) biomarkers are unclear. Methods: Forty-five participants (healthy controls (HC) = 31, MCI = 14) completed the Episodic ABM Interview and a battery of memory tests. Thirty-one (HC = 22, MCI = 9) underwent β-amyloid positron emission tomography (PET) and magnetic resonance (MR) imaging. Fourteen participants (HC = 9, MCI = 5) underwent one imaging modality. Results: Unlike PSM, ABM differentiated between diagnostic categories but did not relate to AD biomarkers. Personal semantic memory was related to neocortical β-amyloid burden after adjusting for age and apolipoprotein E (APOE) É4. Autonoetic consciousness was not associated with AD biomarkers, and was not impaired in MCI. Conclusions: Autobiographical memory was impaired in MCI participants but was not related to neocortical amyloid burden, suggesting that personal memory systems are impacted by differing disease mechanisms, rather than being uniformly underpinned by β-amyloid. Episodic and semantic ABM impairment represent an important AD prodrome.

Original language	English
Pages (from-to)	1737-1746
Number of pages	10
Journal	International Psychogeriatrics
Volume	26
Issue number	10
DOIs	https://doi.org/10.1017/S1041610214001136
Publication status	Published - 20 Jun 2014

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Buckley, R. F., Saling, M. M., Irish, M., Ames, D., Rowe, C. C., Villemagne, V. L., Lautenschlager, N. T., Maruff, P., Macaulay, S. L., Martins, R. N., Szoeke, C., Masters, C. L., Rainey-Smith, S. R., Rembach, A., Savage, G., & Ellis, K. A. (2014). Autobiographical narratives relate to Alzheimer's disease biomarkers in older adults. International Psychogeriatrics, 26(10), 1737-1746. https://doi.org/10.1017/S1041610214001136

@article{67f8adf63d814663bad78793a0d9921a,

title = "Autobiographical narratives relate to Alzheimer's disease biomarkers in older adults",

abstract = "Background: Autobiographical memory (ABM), personal semantic memory (PSM), and autonoetic consciousness are affected in individuals with mild cognitive impairment (MCI) but their relationship with Alzheimer's disease (AD) biomarkers are unclear. Methods: Forty-five participants (healthy controls (HC) = 31, MCI = 14) completed the Episodic ABM Interview and a battery of memory tests. Thirty-one (HC = 22, MCI = 9) underwent β-amyloid positron emission tomography (PET) and magnetic resonance (MR) imaging. Fourteen participants (HC = 9, MCI = 5) underwent one imaging modality. Results: Unlike PSM, ABM differentiated between diagnostic categories but did not relate to AD biomarkers. Personal semantic memory was related to neocortical β-amyloid burden after adjusting for age and apolipoprotein E (APOE) {\'E}4. Autonoetic consciousness was not associated with AD biomarkers, and was not impaired in MCI. Conclusions: Autobiographical memory was impaired in MCI participants but was not related to neocortical amyloid burden, suggesting that personal memory systems are impacted by differing disease mechanisms, rather than being uniformly underpinned by β-amyloid. Episodic and semantic ABM impairment represent an important AD prodrome.",

author = "Buckley, \{Rachel F.\} and Saling, \{Michael M.\} and Muireann Irish and David Ames and Rowe, \{Christopher C.\} and Villemagne, \{Victor L.\} and Lautenschlager, \{Nicola T.\} and Paul Maruff and Macaulay, \{S. Lance\} and Martins, \{Ralph N.\} and Cassandra Szoeke and Masters, \{Colin L.\} and Rainey-Smith, \{Stephanie R.\} and Alan Rembach and Greg Savage and Ellis, \{Kathryn A.\}",

year = "2014",

month = jun,

day = "20",

doi = "10.1017/S1041610214001136",

language = "English",

volume = "26",

pages = "1737--1746",

journal = "International Psychogeriatrics",

issn = "1041-6102",

publisher = "Elsevier",

number = "10",

}

Buckley, RF, Saling, MM, Irish, M, Ames, D, Rowe, CC, Villemagne, VL, Lautenschlager, NT, Maruff, P, Macaulay, SL, Martins, RN, Szoeke, C, Masters, CL, Rainey-Smith, SR, Rembach, A, Savage, G & Ellis, KA 2014, 'Autobiographical narratives relate to Alzheimer's disease biomarkers in older adults', International Psychogeriatrics, vol. 26, no. 10, pp. 1737-1746. https://doi.org/10.1017/S1041610214001136

TY - JOUR

T1 - Autobiographical narratives relate to Alzheimer's disease biomarkers in older adults

AU - Buckley, Rachel F.

AU - Saling, Michael M.

AU - Irish, Muireann

AU - Ames, David

AU - Rowe, Christopher C.

AU - Villemagne, Victor L.

AU - Lautenschlager, Nicola T.

AU - Maruff, Paul

AU - Macaulay, S. Lance

AU - Martins, Ralph N.

AU - Szoeke, Cassandra

AU - Masters, Colin L.

AU - Rainey-Smith, Stephanie R.

AU - Rembach, Alan

AU - Savage, Greg

AU - Ellis, Kathryn A.

PY - 2014/6/20

Y1 - 2014/6/20

N2 - Background: Autobiographical memory (ABM), personal semantic memory (PSM), and autonoetic consciousness are affected in individuals with mild cognitive impairment (MCI) but their relationship with Alzheimer's disease (AD) biomarkers are unclear. Methods: Forty-five participants (healthy controls (HC) = 31, MCI = 14) completed the Episodic ABM Interview and a battery of memory tests. Thirty-one (HC = 22, MCI = 9) underwent β-amyloid positron emission tomography (PET) and magnetic resonance (MR) imaging. Fourteen participants (HC = 9, MCI = 5) underwent one imaging modality. Results: Unlike PSM, ABM differentiated between diagnostic categories but did not relate to AD biomarkers. Personal semantic memory was related to neocortical β-amyloid burden after adjusting for age and apolipoprotein E (APOE) É4. Autonoetic consciousness was not associated with AD biomarkers, and was not impaired in MCI. Conclusions: Autobiographical memory was impaired in MCI participants but was not related to neocortical amyloid burden, suggesting that personal memory systems are impacted by differing disease mechanisms, rather than being uniformly underpinned by β-amyloid. Episodic and semantic ABM impairment represent an important AD prodrome.

AB - Background: Autobiographical memory (ABM), personal semantic memory (PSM), and autonoetic consciousness are affected in individuals with mild cognitive impairment (MCI) but their relationship with Alzheimer's disease (AD) biomarkers are unclear. Methods: Forty-five participants (healthy controls (HC) = 31, MCI = 14) completed the Episodic ABM Interview and a battery of memory tests. Thirty-one (HC = 22, MCI = 9) underwent β-amyloid positron emission tomography (PET) and magnetic resonance (MR) imaging. Fourteen participants (HC = 9, MCI = 5) underwent one imaging modality. Results: Unlike PSM, ABM differentiated between diagnostic categories but did not relate to AD biomarkers. Personal semantic memory was related to neocortical β-amyloid burden after adjusting for age and apolipoprotein E (APOE) É4. Autonoetic consciousness was not associated with AD biomarkers, and was not impaired in MCI. Conclusions: Autobiographical memory was impaired in MCI participants but was not related to neocortical amyloid burden, suggesting that personal memory systems are impacted by differing disease mechanisms, rather than being uniformly underpinned by β-amyloid. Episodic and semantic ABM impairment represent an important AD prodrome.

UR - https://www.scopus.com/pages/publications/84931571275

U2 - 10.1017/S1041610214001136

DO - 10.1017/S1041610214001136

M3 - Article

C2 - 24969443

AN - SCOPUS:84931571275

SN - 1041-6102

VL - 26

SP - 1737

EP - 1746

JO - International Psychogeriatrics

JF - International Psychogeriatrics

IS - 10

ER -

Autobiographical narratives relate to Alzheimer's disease biomarkers in older adults

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