TY - JOUR
T1 - Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes
T2 - A pooled analysis within the InterLymph Consortium
AU - Smedby, Karin Ekström
AU - Vajdic, Claire M.
AU - Falster, Michael
AU - Engels, Eric A.
AU - Martinez-Maza, Otoniel
AU - Turner, Jennifer
AU - Hjalgrim, Henrik
AU - Vineis, Paolo
AU - Costantini, Adele Seniori
AU - Bracci, Paige M.
AU - Holly, Elizabeth A.
AU - Willett, Eleanor
AU - Spinelli, John J.
AU - Vecchia, Carlo La
AU - Zheng, Tongzhang
AU - Becker, Nikolaus
AU - De Sanjosé, Silvia
AU - Chiu, Brian C H
AU - Maso, Luigino Dal
AU - Cocco, Pierluigi
AU - Maynadie, Marc
AU - Foretova, Lenka
AU - Staines, Anthony
AU - Brennan, Paul
AU - Davis, Scott
AU - Severson, Richard
AU - Cerhan, James R.
AU - Breen, Elizabeth C.
AU - Birmann, Brenda
AU - Grulich, Andrew E.
AU - Cozen, Wendy
PY - 2008/4/15
Y1 - 2008/4/15
N2 - Some autoimmune disorders are increasingly recognized as risk factors for non-Hodgkin lymphoma (NHL) overall, but large-scale systematic assessments of risk of NHL subtypes are lacking. We performed a pooled analysis of self-reported autoimmune conditions and risk of NHL and subtypes, including 29 423 participants in 12 case-control studies. We computed pooled odds ratios (OR) and 95% confidence intervals (CI) in a joint fixed-effects model. Sjögren syndrome was associated with a 6.5-fold increased risk of NHL, a 1000-fold increased risk of parotid gland marginal zone lymphoma (OR = 996; 95% CI, 216-4596), and with diffuse large B-cell and follicular lymphomas. Systemic lupus erythematosus was associated with a 2.7-fold increased risk of NHL and with diffuse large B-cell and marginal zone lymphomas. Hemolytic anemia was associated with diffuse large B-cell NHL. T-cell NHL risk was increased for patients with celiac disease and psoriasis. Results for rheumatoid arthritis were heterogeneous between studies. Inflammatory bowel disorders, type 1 diabetes, sarcoidosis, pernicious anemia, and multiple sclerosis were not associated with risk of NHL or subtypes. Thus, specific autoimmune disorders are associated with NHL risk beyond the development of rare NHL subtypes in affected organs. The pattern of associations with NHL subtypes may harbor clues to lym-phomagenesis.
AB - Some autoimmune disorders are increasingly recognized as risk factors for non-Hodgkin lymphoma (NHL) overall, but large-scale systematic assessments of risk of NHL subtypes are lacking. We performed a pooled analysis of self-reported autoimmune conditions and risk of NHL and subtypes, including 29 423 participants in 12 case-control studies. We computed pooled odds ratios (OR) and 95% confidence intervals (CI) in a joint fixed-effects model. Sjögren syndrome was associated with a 6.5-fold increased risk of NHL, a 1000-fold increased risk of parotid gland marginal zone lymphoma (OR = 996; 95% CI, 216-4596), and with diffuse large B-cell and follicular lymphomas. Systemic lupus erythematosus was associated with a 2.7-fold increased risk of NHL and with diffuse large B-cell and marginal zone lymphomas. Hemolytic anemia was associated with diffuse large B-cell NHL. T-cell NHL risk was increased for patients with celiac disease and psoriasis. Results for rheumatoid arthritis were heterogeneous between studies. Inflammatory bowel disorders, type 1 diabetes, sarcoidosis, pernicious anemia, and multiple sclerosis were not associated with risk of NHL or subtypes. Thus, specific autoimmune disorders are associated with NHL risk beyond the development of rare NHL subtypes in affected organs. The pattern of associations with NHL subtypes may harbor clues to lym-phomagenesis.
UR - http://www.scopus.com/inward/record.url?scp=43249104448&partnerID=8YFLogxK
U2 - 10.1182/blood-2007-10-119974
DO - 10.1182/blood-2007-10-119974
M3 - Article
C2 - 18263783
AN - SCOPUS:43249104448
SN - 0006-4971
VL - 111
SP - 4029
EP - 4038
JO - Blood
JF - Blood
IS - 8
ER -