Automated radiosynthesis of [18F]PBR111 and [18F]PBR102 using the Tracerlab FXFN and Tracerlab MXFDG module for imaging the peripheral benzodiazepine receptor with PET

Thomas Bourdier*, Tien Q. Pham, David Henderson, Timothy Jackson, Peter Lam, Michael Izard, Andrew Katsifis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

[18F]PBR111 and [18F]PBR102 are selective radioligands for imaging of the Peripheral Benzodiazepine Receptor (PBR). We have developed a fully automated method for the radiosynthesis of [18F]PBR111 and [18F]PBR102 in the Tracerlab FXFN (30±2% radiochemical yield non-decay-corrected for both tracers) and Tracerlab MXFDG (25±2% radiochemical yield non-decay-corrected for both tracers) from the corresponding p-toluenesulfonyl precursors. For all tracers, radiochemical purity was >99% and specific activity was >150GBq/μmol after less than 60min of preparation time.

Original languageEnglish
Pages (from-to)176-183
Number of pages8
JournalApplied Radiation and Isotopes
Volume70
Issue number1
DOIs
Publication statusPublished - Jan 2012
Externally publishedYes

Keywords

  • [F]fluorination
  • [F]PBR102
  • [F]PBR111
  • Tracerlab FX
  • Tracerlab MX

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