Automated radiosynthesis of [18F]PBR111 and [18F]PBR102 using the Tracerlab FXFN and Tracerlab MXFDG module for imaging the peripheral benzodiazepine receptor with PET

Thomas Bourdier; Tien Q. Pham; David Henderson; Timothy Jackson; Peter Lam; Michael Izard; Andrew Katsifis

doi:10.1016/j.apradiso.2011.07.014

Automated radiosynthesis of [¹⁸F]PBR111 and [¹⁸F]PBR102 using the Tracerlab FX_FN and Tracerlab MX_FDG module for imaging the peripheral benzodiazepine receptor with PET

Thomas Bourdier^*, Tien Q. Pham, David Henderson, Timothy Jackson, Peter Lam, Michael Izard, Andrew Katsifis

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

[¹⁸F]PBR111 and [¹⁸F]PBR102 are selective radioligands for imaging of the Peripheral Benzodiazepine Receptor (PBR). We have developed a fully automated method for the radiosynthesis of [¹⁸F]PBR111 and [¹⁸F]PBR102 in the Tracerlab FX_FN (30±2% radiochemical yield non-decay-corrected for both tracers) and Tracerlab MX_FDG (25±2% radiochemical yield non-decay-corrected for both tracers) from the corresponding p-toluenesulfonyl precursors. For all tracers, radiochemical purity was >99% and specific activity was >150GBq/μmol after less than 60min of preparation time.

Original language	English
Pages (from-to)	176-183
Number of pages	8
Journal	Applied Radiation and Isotopes
Volume	70
Issue number	1
DOIs	https://doi.org/10.1016/j.apradiso.2011.07.014
Publication status	Published - Jan 2012
Externally published	Yes

Keywords

[F]fluorination
[F]PBR102
[F]PBR111
Tracerlab FX
Tracerlab MX

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10.1016/j.apradiso.2011.07.014

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abstract = "[18F]PBR111 and [18F]PBR102 are selective radioligands for imaging of the Peripheral Benzodiazepine Receptor (PBR). We have developed a fully automated method for the radiosynthesis of [18F]PBR111 and [18F]PBR102 in the Tracerlab FXFN (30±2% radiochemical yield non-decay-corrected for both tracers) and Tracerlab MXFDG (25±2% radiochemical yield non-decay-corrected for both tracers) from the corresponding p-toluenesulfonyl precursors. For all tracers, radiochemical purity was >99% and specific activity was >150GBq/μmol after less than 60min of preparation time.",

keywords = "[F]fluorination, [F]PBR102, [F]PBR111, Tracerlab FX, Tracerlab MX",

author = "Thomas Bourdier and Pham, {Tien Q.} and David Henderson and Timothy Jackson and Peter Lam and Michael Izard and Andrew Katsifis",

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doi = "10.1016/j.apradiso.2011.07.014",

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AU - Bourdier, Thomas

AU - Pham, Tien Q.

AU - Henderson, David

AU - Jackson, Timothy

AU - Lam, Peter

AU - Izard, Michael

AU - Katsifis, Andrew

PY - 2012/1

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AB - [18F]PBR111 and [18F]PBR102 are selective radioligands for imaging of the Peripheral Benzodiazepine Receptor (PBR). We have developed a fully automated method for the radiosynthesis of [18F]PBR111 and [18F]PBR102 in the Tracerlab FXFN (30±2% radiochemical yield non-decay-corrected for both tracers) and Tracerlab MXFDG (25±2% radiochemical yield non-decay-corrected for both tracers) from the corresponding p-toluenesulfonyl precursors. For all tracers, radiochemical purity was >99% and specific activity was >150GBq/μmol after less than 60min of preparation time.

KW - [F]fluorination

KW - [F]PBR102

KW - [F]PBR111

KW - Tracerlab FX

KW - Tracerlab MX

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Automated radiosynthesis of [¹⁸F]PBR111 and [¹⁸F]PBR102 using the Tracerlab FX_FN and Tracerlab MX_FDG module for imaging the peripheral benzodiazepine receptor with PET

Abstract

Keywords

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