Autophagy as a decisive process for cell death

Seonghee Jung; Hyeongjeong Jeong; Seong-Woon Yu

doi:10.1038/s12276-020-0455-4

Autophagy as a decisive process for cell death

Seonghee Jung, Hyeongjeong Jeong, Seong-Woon Yu^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

274 Citations (Scopus)

231 Downloads (Pure)

Abstract

Autophagy is an intracellular catabolic pathway in which cellular constituents are engulfed by autophagosomes and degraded upon autophagosome fusion with lysosomes. Autophagy serves as a major cytoprotective process by maintaining cellular homeostasis and recycling cytoplasmic contents. However, emerging evidence suggests that autophagy is a primary mechanism of cell death (autophagic cell death, ACD) and implicates ACD in several aspects of mammalian physiology, including tumor suppression and psychological disorders. However, little is known about the physiological roles and molecular mechanisms of ACD. In this review, we document examples of ACD and discuss recent progress in our understanding of its molecular mechanisms.

Original language	English
Pages (from-to)	921-930
Number of pages	10
Journal	Experimental and Molecular Medicine
Volume	52
Issue number	6
DOIs	https://doi.org/10.1038/s12276-020-0455-4
Publication status	Published - 26 Jun 2020
Externally published	Yes

Bibliographical note

Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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title = "Autophagy as a decisive process for cell death",

abstract = "Autophagy is an intracellular catabolic pathway in which cellular constituents are engulfed by autophagosomes and degraded upon autophagosome fusion with lysosomes. Autophagy serves as a major cytoprotective process by maintaining cellular homeostasis and recycling cytoplasmic contents. However, emerging evidence suggests that autophagy is a primary mechanism of cell death (autophagic cell death, ACD) and implicates ACD in several aspects of mammalian physiology, including tumor suppression and psychological disorders. However, little is known about the physiological roles and molecular mechanisms of ACD. In this review, we document examples of ACD and discuss recent progress in our understanding of its molecular mechanisms.",

author = "Seonghee Jung and Hyeongjeong Jeong and Seong-Woon Yu",

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AU - Jung, Seonghee

AU - Jeong, Hyeongjeong

AU - Yu, Seong-Woon

N1 - Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2020/6/26

Y1 - 2020/6/26

N2 - Autophagy is an intracellular catabolic pathway in which cellular constituents are engulfed by autophagosomes and degraded upon autophagosome fusion with lysosomes. Autophagy serves as a major cytoprotective process by maintaining cellular homeostasis and recycling cytoplasmic contents. However, emerging evidence suggests that autophagy is a primary mechanism of cell death (autophagic cell death, ACD) and implicates ACD in several aspects of mammalian physiology, including tumor suppression and psychological disorders. However, little is known about the physiological roles and molecular mechanisms of ACD. In this review, we document examples of ACD and discuss recent progress in our understanding of its molecular mechanisms.

AB - Autophagy is an intracellular catabolic pathway in which cellular constituents are engulfed by autophagosomes and degraded upon autophagosome fusion with lysosomes. Autophagy serves as a major cytoprotective process by maintaining cellular homeostasis and recycling cytoplasmic contents. However, emerging evidence suggests that autophagy is a primary mechanism of cell death (autophagic cell death, ACD) and implicates ACD in several aspects of mammalian physiology, including tumor suppression and psychological disorders. However, little is known about the physiological roles and molecular mechanisms of ACD. In this review, we document examples of ACD and discuss recent progress in our understanding of its molecular mechanisms.

UR - https://www.scopus.com/pages/publications/85086851268

U2 - 10.1038/s12276-020-0455-4

DO - 10.1038/s12276-020-0455-4

M3 - Review article

C2 - 32591647

SN - 1226-3613

VL - 52

SP - 921

EP - 930

JO - Experimental and Molecular Medicine

JF - Experimental and Molecular Medicine

IS - 6

ER -

Autophagy as a decisive process for cell death

Abstract

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