Autophagy in endocrine tumors

Andrea Weckman, Fabio Rotondo*, Antonio Di Ieva, Luis V. Syro, Henriett Butz, Michael D. Cusimano, Kalman Kovacs

*Corresponding author for this work

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

Autophagy is an important intracellular process involving the degradation of cytoplasmic components. It is involved in both physiological and pathological conditions, including cancer. The role of autophagy in cancer is described as a 'double-edged sword,' a term that reflects its known participation in tumor suppression, tumor survival and tumor cell proliferation. Available research regarding autophagy in endocrine cancer supports this concept. Autophagy shows promise as a novel therapeutic target in different types of endocrine cancer, inhibiting or increasing treatment efficacy in a context- and cell-typedependent manner. At present, however, there is very little research concerning autophagy in endocrine tumors. No research was reported connecting autophagy to some of the tumors of the endocrine glands such as the pancreas and ovary. This review aims to elucidate the roles of autophagy in different types of endocrine cancer and highlight the need for increased research in the field.

Original languageEnglish
Pages (from-to)R205-R218
Number of pages14
JournalEndocrine-Related Cancer
Volume22
Issue number4
DOIs
Publication statusPublished - 1 Aug 2015
Externally publishedYes

Keywords

  • Autophagy
  • Autophagy modulation
  • Endocrine disease
  • Neoplasia
  • Therapeutic poten

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    Weckman, A., Rotondo, F., Di Ieva, A., Syro, L. V., Butz, H., Cusimano, M. D., & Kovacs, K. (2015). Autophagy in endocrine tumors. Endocrine-Related Cancer, 22(4), R205-R218. https://doi.org/10.1530/ERC-15-0042