Autosomal dominant polycystic kidney disease

Autosomal dominant polycystic kidney disease (ADPKD) occurs uniformly throughout the world. ADPKD has high intrafamilial and interfamilial heterogeneity due to environmental mechanisms and modifying genes. This chapter summarizes the treatment of ADPKD. It presents a summary of diagnostic tests in ADPKD. The chapter explores the clinical value of methods that are used to predict renal prognosis in individual patients. It provides an overview of the management approach in a patient with ADPKD. The management of ADPKD should be "patient-centered" and "personalized". The provision of coordinated genetic, medical, and psychosocial care should be the overarching goal of care. The chapter shows the frequency of extrarenal manifestations. Psychological morbidity followed by the cardiovascular and gastrointestinal systems are the most commonly affected extrarenal areas. Patients with ADPKD were historically suspected to have an increased incidence of malignancy, but data to support this hypothesis is inconsistent.