Axonal loss in nonoptic neuritis eyes of patients with multiple sclerosis linked to delayed visual evoked potential

Alexandr Klistorner*, Raymond Garrick, Michael H. Barnett, Stuart L. Graham, Hemamalini Arvind, Prema Sriram, Con Yiannikas

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    51 Citations (Scopus)


    Objective: Recent studies demonstrate significant thinning of the retinal nerve fiber layer (RNFL) in multiple sclerosis (MS) nonoptic neuritis (MS-NON) eyes. However, the pathologic basis of this reduction is not clear. The aim of the current study was to investigate the relationship of the RNFL thickness in MS-NON eyes with latency delay of the multifocal visual evoked potential (mfVEP), a surrogate marker of the visual pathway demyelination.

    Methods: Total and temporal RNFL thickness and latency of the mfVEP in 45 MS-NON eyes of 45 patients with relapsing-remitting MS and 25 eyes of age-and gender-matched controls were measured and analyzed.

    Results: There was significant reduction of total and temporal RNFL thickness (p = 0.015 and p = 0.006, respectively) and significant latency delay (p < 0.0001) in MS-NON eyes. Both total and temporal RNFL thickness were associated with latency of the mfVEP (r2 = 0.43, p < 0.0001 and r2 = 0.36, p = 0.001, respectively). MS-NON eyes with normal latency (n = 26) showed no significant reduction of RNFL thickness compared with controls (p = 0.44 and p = 0.1 for total and temporal RNFL, respectively), whereas eyes with delayed latency (n = 19) demonstrated significantly thinner RNFL (p = 0.001 and p = 0.0005). MS-NON eyes with delayed latency also had significantly thinner RNFL compared with those with normal latencies (p = 0.013 and p = 0.02). In patients with no previous optic neuritis in either eye, delayed latency and reduced RNFL were bilateral whenever present.

    Conclusions: The study demonstrated significant association between RNFL loss and a latency delay of the mfVEP in MS-NON eyes.

    Original languageEnglish
    Pages (from-to)242-245
    Number of pages4
    Issue number3
    Publication statusPublished - 15 Jan 2013


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