Axonal loss of retinal neurons in multiple sclerosis associated with optic radiation lesions

Alexander Klistorner*, Prima Sriram, Nikitha Vootakuru, Chenyu Wang, Michael H. Barnett, Raymond Garrick, John Parratt, Netta Levin, Noa Raz, Anneke Van Der Walt, Lynette Masters, Stuart L. Graham, Con Yiannikas

*Corresponding author for this work

    Research output: Contribution to journalArticle

    68 Citations (Scopus)

    Abstract

    Objective: To investigate the potential links between thinning of retinal ganglion cell axons in eyes of patients with multiple sclerosis (MS) without past optic neuritis (ON) and MS-related inflammatory damage of the posterior visual pathway. Methods: Temporal retinal nerve fiber layer (tRNFL) thickness was analyzed in eyes with no history of ON (NON) from 53 patients with relapsing-remitting MS. Fifty normal age- and sexmatched controls were examined with optical coherence tomography. Low-contrast visual acuity charts were used for functional assessment of vision. The optic tract (OT) and optic radiation (OR) were identified using probabilistic tractography, and volume of T2 fluid-attenuated inversion recovery lesions and diffusion tensor imaging (DTI) indices were measured within both structures. Cross-sectional diameter of the OT was also calculated. Results: tRNFL thickness was significantly reduced in NON eyes and was associated with reduced low-contrast visual acuity. Lesions within the OR were detected in the majority of patients. There was a significant correlation between thinning of the tRNFL and OR lesion volume (adjusted for non-OR lesion volume, age, sex, and disease duration). tRNFL thickness also correlated with OR DTI indices. No OT lesions were identified in any of the patients and no relationship between retinal nerve fiber layer loss and potential markers of OT lesions was found. Conclusion: The results demonstrate a strong tract-specific association between loss of tRNFL fibers and MS-related inflammation within OR.

    Original languageEnglish
    Pages (from-to)2165-2172
    Number of pages8
    JournalNeurology
    Volume82
    Issue number24
    DOIs
    Publication statusPublished - 17 Jun 2014

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    Klistorner, A., Sriram, P., Vootakuru, N., Wang, C., Barnett, M. H., Garrick, R., ... Yiannikas, C. (2014). Axonal loss of retinal neurons in multiple sclerosis associated with optic radiation lesions. Neurology, 82(24), 2165-2172. https://doi.org/10.1212/WNL.0000000000000522