B-cell activity markers are associated with different disease activity domains in primary Sjögren's syndrome

Katherine James, Chimwemwe Chipeta, Antony Parker, Stephen Harding, Simon J. Cockell, Colin S. Gillespie, Jennifer Hallinan, Francesca Barone, Simon J. Bowman, Wan Fai Ng, Benjamin A. Fisher*, UK Primary Sjögren's Syndrome Registry

*Corresponding author for this work

Research output: Contribution to journalArticle

9 Citations (Scopus)
1 Downloads (Pure)

Abstract

Objectives. B-cell activating factor (BAFF), β-2 microglobulin (β2M) and serum free light chains (FLCs) are elevated in primary SS (pSS) and associated with disease activity. We aimed to investigate their association with the individual disease activity domains of the EULAR Sjögren's Syndrome Disease Activity Index (ESSDAI) in a large well-characterized pSS cohort. Methods. Sera from pSS patients enrolled in the UK Primary Sjögren's Syndrome Registry (UKPSSR) (n = 553) and healthy controls (n = 286) were analysed for FLC (κ and λ), BAFF and β2M. Pearson correlation coefficients were calculated for patient clinical characteristics, including salivary flow, Schirmer's test, EULAR Sjögren's Syndrome Patient Reported Index and serum IgG levels. Poisson regression was performed to identify independent predictors of total ESSDAI and ClinESSDAI (validated ESSDAI minus the biological domain) scores and their domains. Results. Levels of BAFF, β2M and FLCs were higher in pSS patients compared to controls. All three biomarkers associated significantly with the ESSDAI and the ClinESSDAI. BAFF associated with the peripheral nervous system domain of the ESSDAI, whereas β2M and FLCs associated with the cutaneous, biological and renal domains. Multivariate analysis showed BAFF, β2M and their interaction to be independent predictors of ESSDAI/ClinESSDAI. FLCs were also shown to associate with the ESSDAI/ ClinESSDAI but not independent of serum IgG. Conclusion. All biomarkers were associated with total ESSDAI scores but with differing domain associations. These findings should encourage further investigation of these biomarkers in longitudinal studies and against other disease activity measures.

Original languageEnglish
Pages (from-to)1222-1227
Number of pages6
JournalRheumatology (United Kingdom)
Volume57
Issue number7
DOIs
Publication statusPublished - Jul 2018

Bibliographical note

Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Sjögren's syndrome
  • B cells
  • B-cell activating factor
  • β-2 microglobulin
  • free light chains
  • disease activity
  • biomarker

Fingerprint Dive into the research topics of 'B-cell activity markers are associated with different disease activity domains in primary Sjögren's syndrome'. Together they form a unique fingerprint.

  • Cite this

    James, K., Chipeta, C., Parker, A., Harding, S., Cockell, S. J., Gillespie, C. S., ... UK Primary Sjögren's Syndrome Registry (2018). B-cell activity markers are associated with different disease activity domains in primary Sjögren's syndrome. Rheumatology (United Kingdom), 57(7), 1222-1227. https://doi.org/10.1093/rheumatology/key063