B-vitamins reduce plasma levels of beta amyloid

Leon Flicker; Ralph N. Martins; Jenny Thomas; John Acres; Kevin Taddei; Samuel D. Vasikaran; Paul Norman; Konrad Jamrozik; Osvaldo P. Almeida

doi:10.1016/j.neurobiolaging.2006.10.007

B-vitamins reduce plasma levels of beta amyloid

Leon Flicker^*, Ralph N. Martins, Jenny Thomas, John Acres, Kevin Taddei, Samuel D. Vasikaran, Paul Norman, Konrad Jamrozik, Osvaldo P. Almeida

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

Elevated plasma homocysteine (tHcy) is a risk factor for Alzheimer's disease (AD), and thus B vitamins may have a role in the prevention of AD. The objective of this study was to determine if tHcy lowering vitamins decrease the circulating levels of A-beta protein 1-40 (Aβ40). We randomized 299 older men to treatment with 2 mg of folate, plus 25 mg of B6 and 400 μg of B12, or placebo. After 2 years of treatment the mean (S.E.) increase of Aβ40 was 7.0 pg/ml (8.4) in the vitamin group (4.9%), and 26.8 pg/ml (7.7) (18.5%) in the placebo group. We conclude that B vitamins may decrease the plasma level of Aβ40 and have a role in the prevention of AD.

Original language	English
Pages (from-to)	303-305
Number of pages	3
Journal	Neurobiology of Aging
Volume	29
Issue number	2
DOIs	https://doi.org/10.1016/j.neurobiolaging.2006.10.007
Publication status	Published - Feb 2008
Externally published	Yes

Keywords

Alzheimer
Amyloid beta protein
B vitamins

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10.1016/j.neurobiolaging.2006.10.007

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title = "B-vitamins reduce plasma levels of beta amyloid",

abstract = "Elevated plasma homocysteine (tHcy) is a risk factor for Alzheimer's disease (AD), and thus B vitamins may have a role in the prevention of AD. The objective of this study was to determine if tHcy lowering vitamins decrease the circulating levels of A-beta protein 1-40 (Aβ40). We randomized 299 older men to treatment with 2 mg of folate, plus 25 mg of B6 and 400 μg of B12, or placebo. After 2 years of treatment the mean (S.E.) increase of Aβ40 was 7.0 pg/ml (8.4) in the vitamin group (4.9%), and 26.8 pg/ml (7.7) (18.5%) in the placebo group. We conclude that B vitamins may decrease the plasma level of Aβ40 and have a role in the prevention of AD.",

keywords = "Alzheimer, Amyloid beta protein, B vitamins",

author = "Leon Flicker and Martins, {Ralph N.} and Jenny Thomas and John Acres and Kevin Taddei and Vasikaran, {Samuel D.} and Paul Norman and Konrad Jamrozik and Almeida, {Osvaldo P.}",

year = "2008",

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doi = "10.1016/j.neurobiolaging.2006.10.007",

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AU - Flicker, Leon

AU - Martins, Ralph N.

AU - Thomas, Jenny

AU - Acres, John

AU - Taddei, Kevin

AU - Vasikaran, Samuel D.

AU - Norman, Paul

AU - Jamrozik, Konrad

AU - Almeida, Osvaldo P.

PY - 2008/2

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AB - Elevated plasma homocysteine (tHcy) is a risk factor for Alzheimer's disease (AD), and thus B vitamins may have a role in the prevention of AD. The objective of this study was to determine if tHcy lowering vitamins decrease the circulating levels of A-beta protein 1-40 (Aβ40). We randomized 299 older men to treatment with 2 mg of folate, plus 25 mg of B6 and 400 μg of B12, or placebo. After 2 years of treatment the mean (S.E.) increase of Aβ40 was 7.0 pg/ml (8.4) in the vitamin group (4.9%), and 26.8 pg/ml (7.7) (18.5%) in the placebo group. We conclude that B vitamins may decrease the plasma level of Aβ40 and have a role in the prevention of AD.

KW - Alzheimer

KW - Amyloid beta protein

KW - B vitamins

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B-vitamins reduce plasma levels of beta amyloid

Abstract

Keywords

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