B-vitamins reduce plasma levels of beta amyloid

Leon Flicker*, Ralph N. Martins, Jenny Thomas, John Acres, Kevin Taddei, Samuel D. Vasikaran, Paul Norman, Konrad Jamrozik, Osvaldo P. Almeida

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)


Elevated plasma homocysteine (tHcy) is a risk factor for Alzheimer's disease (AD), and thus B vitamins may have a role in the prevention of AD. The objective of this study was to determine if tHcy lowering vitamins decrease the circulating levels of A-beta protein 1-40 (Aβ40). We randomized 299 older men to treatment with 2 mg of folate, plus 25 mg of B6 and 400 μg of B12, or placebo. After 2 years of treatment the mean (S.E.) increase of Aβ40 was 7.0 pg/ml (8.4) in the vitamin group (4.9%), and 26.8 pg/ml (7.7) (18.5%) in the placebo group. We conclude that B vitamins may decrease the plasma level of Aβ40 and have a role in the prevention of AD.

Original languageEnglish
Pages (from-to)303-305
Number of pages3
JournalNeurobiology of Aging
Issue number2
Publication statusPublished - Feb 2008
Externally publishedYes


  • Alzheimer
  • Amyloid beta protein
  • B vitamins


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