Bacterial cell division

Experimental and theoretical approaches to the divisome

Claire E. Broughton, David I. Roper, Hugo A. van den Berg, Alison Rodger

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cell division is a key event in the bacterial life cycle. It involves constriction at the midcell, so that one cell can give rise to two daughter cells. This constriction is mediated by a ring composed of fibrous multimers of the protein FtsZ. However, a host of additional factors is involved in the formation and dynamics of this “Z‑ring” and this complicated apparatus is collectively known as the “divisome”. We review the literature, with an emphasis on mathematical modelling, and show how such theoretical efforts have helped experimentalists to make sense of the at times bewildering data, and plan further experiments.

Original languageEnglish
Pages (from-to)313-345
Number of pages33
JournalScience Progress
Volume98
Issue number4
DOIs
Publication statusPublished - 1 Dec 2015
Externally publishedYes

Keywords

  • Bacterial cell division
  • Divisome
  • FtsA
  • FtsZ
  • Mathematical modelling
  • ZipA
  • Z‑ring

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