Bactericidal and cyclooxygenase inhibitory diterpenes from Eremophila sturtii

Qian Liu, David Harrington, James L. Kohen, Subramanyam Vemulpad, Joanne F. Jamie

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Two serrulatane diterpenes, 3,8-dihydroxyserrulatic acid (1) and serrulatic acid (2), have been isolated from Eremophila sturtii through bioassay-guided fractionation. These compounds inhibit the inflammation pathway enzymes cyclooxygenase 1 and 2, and exhibit bactericidal activity against Staphylococcus aureus.

LanguageEnglish
Pages1256-1261
Number of pages6
JournalPhytochemistry
Volume67
Issue number12
DOIs
Publication statusPublished - Jun 2006

Fingerprint

Cyclooxygenase 1
Bioassay
Diterpenes
prostaglandin synthase
Cyclooxygenase 2
Prostaglandin-Endoperoxide Synthases
Fractionation
diterpenoids
Biological Assay
Staphylococcus aureus
Inflammation
acids
Enzymes
fractionation
bioassays
inflammation
enzymes
serrulatic acid
3,8-dihydroxyserrulatic acid

Cite this

Liu, Qian ; Harrington, David ; Kohen, James L. ; Vemulpad, Subramanyam ; Jamie, Joanne F. / Bactericidal and cyclooxygenase inhibitory diterpenes from Eremophila sturtii. In: Phytochemistry. 2006 ; Vol. 67, No. 12. pp. 1256-1261.
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Bactericidal and cyclooxygenase inhibitory diterpenes from Eremophila sturtii. / Liu, Qian; Harrington, David; Kohen, James L.; Vemulpad, Subramanyam; Jamie, Joanne F.

In: Phytochemistry, Vol. 67, No. 12, 06.2006, p. 1256-1261.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Liu, Qian

AU - Harrington, David

AU - Kohen, James L.

AU - Vemulpad, Subramanyam

AU - Jamie, Joanne F.

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T2 - Phytochemistry

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