Bactericidal and cyclooxygenase inhibitory diterpenes from Eremophila sturtii

Qian Liu, David Harrington, James L. Kohen, Subramanyam Vemulpad, Joanne F. Jamie*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    40 Citations (Scopus)

    Abstract

    Two serrulatane diterpenes, 3,8-dihydroxyserrulatic acid (1) and serrulatic acid (2), have been isolated from Eremophila sturtii through bioassay-guided fractionation. These compounds inhibit the inflammation pathway enzymes cyclooxygenase 1 and 2, and exhibit bactericidal activity against Staphylococcus aureus.

    Original languageEnglish
    Pages (from-to)1256-1261
    Number of pages6
    JournalPhytochemistry
    Volume67
    Issue number12
    DOIs
    Publication statusPublished - Jun 2006

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