Bactericidal and cyclooxygenase inhibitory diterpenes from Eremophila sturtii

Qian Liu; David Harrington; James L. Kohen; Subramanyam Vemulpad; Joanne F. Jamie

doi:10.1016/j.phytochem.2006.04.014

Bactericidal and cyclooxygenase inhibitory diterpenes from Eremophila sturtii

Qian Liu, David Harrington, James L. Kohen, Subramanyam Vemulpad, Joanne F. Jamie^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Two serrulatane diterpenes, 3,8-dihydroxyserrulatic acid (1) and serrulatic acid (2), have been isolated from Eremophila sturtii through bioassay-guided fractionation. These compounds inhibit the inflammation pathway enzymes cyclooxygenase 1 and 2, and exhibit bactericidal activity against Staphylococcus aureus.

Original language	English
Pages (from-to)	1256-1261
Number of pages	6
Journal	Phytochemistry
Volume	67
Issue number	12
DOIs	https://doi.org/10.1016/j.phytochem.2006.04.014
Publication status	Published - Jun 2006

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10.1016/j.phytochem.2006.04.014

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title = "Bactericidal and cyclooxygenase inhibitory diterpenes from Eremophila sturtii",

abstract = "Two serrulatane diterpenes, 3,8-dihydroxyserrulatic acid (1) and serrulatic acid (2), have been isolated from Eremophila sturtii through bioassay-guided fractionation. These compounds inhibit the inflammation pathway enzymes cyclooxygenase 1 and 2, and exhibit bactericidal activity against Staphylococcus aureus.",

author = "Qian Liu and David Harrington and Kohen, {James L.} and Subramanyam Vemulpad and Jamie, {Joanne F.}",

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AU - Liu, Qian

AU - Harrington, David

AU - Kohen, James L.

AU - Vemulpad, Subramanyam

AU - Jamie, Joanne F.

PY - 2006/6

Y1 - 2006/6

N2 - Two serrulatane diterpenes, 3,8-dihydroxyserrulatic acid (1) and serrulatic acid (2), have been isolated from Eremophila sturtii through bioassay-guided fractionation. These compounds inhibit the inflammation pathway enzymes cyclooxygenase 1 and 2, and exhibit bactericidal activity against Staphylococcus aureus.

AB - Two serrulatane diterpenes, 3,8-dihydroxyserrulatic acid (1) and serrulatic acid (2), have been isolated from Eremophila sturtii through bioassay-guided fractionation. These compounds inhibit the inflammation pathway enzymes cyclooxygenase 1 and 2, and exhibit bactericidal activity against Staphylococcus aureus.

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M3 - Article

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SN - 0031-9422

VL - 67

SP - 1256

EP - 1261

JO - Phytochemistry

JF - Phytochemistry

IS - 12

ER -

Bactericidal and cyclooxygenase inhibitory diterpenes from Eremophila sturtii

Abstract

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