Balancing tolerance and immunity: The role of dendritic cell and T cell subsets

Elena Shklovskaya, Barbara Fazekas Barbara

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

14 Citations (Scopus)

Abstract

The interaction between dendritic cells and T cells is crucial for the regulation of immunological tolerance and immunity. Although our understanding of the mechanisms responsible for these phenomena has advanced significantly in recent years, we are still lacking a fully integrated model of how dendritic cell phenotype correlates with function, and how complex interactions with multiple dendritic and T cell subpopulations shape the course of the immune response in vivo. In this review, we summarize the current state of knowledge in the field, highlighting the areas where further investigation is likely to advance our understanding of this fundamental immunological interaction.

Original languageEnglish
Title of host publicationImmunological Tolerance
Subtitle of host publicationMethods and Protocols
EditorsPaul J. Fairchild
Place of PublicationTotowa, New Jersey
PublisherHumana Press
Pages25-46
Number of pages22
Volume380
ISBN (Print)1597453951, 9781597453950
DOIs
Publication statusPublished - 25 Apr 2007
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume380
ISSN (Print)10643745

Keywords

  • Dendritic cell
  • Immunity
  • T cell
  • Tolerance

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