TY - JOUR
T1 - Baroreceptor sensitivity is reversed in diabetes and is unaffected by anti-hypertensive treatment
T2 - Association for Research into Arterial Structure and Physiology Conference 2013
AU - Kouchaki, Z.
AU - Salum, E.
AU - Kals, J.
AU - Kampus, P.
AU - Avolio, A. P.
AU - Butlin, M.
N1 - Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.
PY - 2013
Y1 - 2013
N2 - Objectives. Diabetes is a complex disease associated with cardiovascular complications. This study compared baroreceptor sensitivity (BRS) in diabetic rats with and without anti-hypertensive treatment. Methods. Diabetes (induced by intraperitoneal injection of streptozotocin at 6 weeks of age) and control (saline injection) rats were divided into untreated (diabetic n=9, control n=5) and treated (diabetes+Tx n=9, control+Tx n=6) groups. Treatment groups received angiotensin II receptor antagonist, telmisartan (10 mg/kg/day, gavage). At 17 weeks of age, systolic pressure was measured by tail-cuff technique. The following week, rats were anaesthetised (urethane, 1.3 g/kg) and aortic pressure and heart rate measured during intravenous phenylephrine infusion (30 ?g/kg/min). BRS was calculated by the slope of heart rate against mean pressure rise. Normal BRS was defined as a positive slope, and BRS dysfunction as a negative slope (Figure). Results. Both control (142?16 mmHg) and diabetic (132?22 mmHg) animals were hypertensive. Anti-hypertensive treatment successfully lowered systolic blood pressure (control+Tx 105?11 mmHg; diabetes+Tx 119?14 mmHg). BRS was typically positive in control (100%) and control+Tx (83%) rats. Conversely, BRS was impaired in both diabetic (33% positive) and diabetes+Tx (29% positive) rats. BRS impairment was significantly different between diabetic and control rats (p=0.007) and diabetes+Tx and control+Tx rats (p=0.002). However, there was no difference with anti-hypertensive treatment (diabetes, diabetes+Tx: p=0.42; control, contol+Tx: p=0.32). Conclusion. Baroreceptor sensitivity is impaired in diabetic rats and this is independent of the hypertensive state.
AB - Objectives. Diabetes is a complex disease associated with cardiovascular complications. This study compared baroreceptor sensitivity (BRS) in diabetic rats with and without anti-hypertensive treatment. Methods. Diabetes (induced by intraperitoneal injection of streptozotocin at 6 weeks of age) and control (saline injection) rats were divided into untreated (diabetic n=9, control n=5) and treated (diabetes+Tx n=9, control+Tx n=6) groups. Treatment groups received angiotensin II receptor antagonist, telmisartan (10 mg/kg/day, gavage). At 17 weeks of age, systolic pressure was measured by tail-cuff technique. The following week, rats were anaesthetised (urethane, 1.3 g/kg) and aortic pressure and heart rate measured during intravenous phenylephrine infusion (30 ?g/kg/min). BRS was calculated by the slope of heart rate against mean pressure rise. Normal BRS was defined as a positive slope, and BRS dysfunction as a negative slope (Figure). Results. Both control (142?16 mmHg) and diabetic (132?22 mmHg) animals were hypertensive. Anti-hypertensive treatment successfully lowered systolic blood pressure (control+Tx 105?11 mmHg; diabetes+Tx 119?14 mmHg). BRS was typically positive in control (100%) and control+Tx (83%) rats. Conversely, BRS was impaired in both diabetic (33% positive) and diabetes+Tx (29% positive) rats. BRS impairment was significantly different between diabetic and control rats (p=0.007) and diabetes+Tx and control+Tx rats (p=0.002). However, there was no difference with anti-hypertensive treatment (diabetes, diabetes+Tx: p=0.42; control, contol+Tx: p=0.32). Conclusion. Baroreceptor sensitivity is impaired in diabetic rats and this is independent of the hypertensive state.
U2 - 10.1016/j.artres.2013.10.123
DO - 10.1016/j.artres.2013.10.123
M3 - Meeting abstract
SN - 1872-9312
VL - 7
SP - 136
JO - Artery Research
JF - Artery Research
IS - 3-4
M1 - P4.04
Y2 - 17 October 2013 through 19 October 2013
ER -