Abstract
Purpose: To report baseline data and methodology for initial cohort of patients recruited to PROGRESSA (Predicting Risk Of Glaucoma : RElevant SNPs with Strong Association) study, aiming to develop predictors of progression for the full range of glaucoma suspects and early glaucoma patients including genetic risk profiling.
Method: Prospective, observational cohort study, recruiting glaucoma suspects based on disc appearance or ocular hypertension, and early manifest glaucoma (EMG) patients with early field loss, (mean deviation better than −5.0 dB).
Results: Initial data for 304 patients, (48.7%) EMG and (51.3%) glaucoma suspects.
Mean age 66.0(+/− 9.7) yrs, mean vertical cup:disc ratio (VCDR) 0.67(+/−0.12), mean IOP 16.10(+/− 3.6) mmHg, mean CCT 543(+/−34) μm.
Average visual field mean deviation −0.87(+/− 1.68) dB.
Comparison of EMG and suspect cohorts suggest higher VCDR, thinner CCT and worse visual field mean deviation in early manifest group, with no difference in IOP.
114 patients (37.5%) currently on medical therapy, 72% using a sole agent, prostaglandin analogue (83%), beta blocker (16%).
64 patients (21%) have had SLT, 31 of these also currently on drops.
Prevalence of risk factors in the study cohort; Migraines (14%), Raynauds phenomenon (5%), Cardiovascular disease (13%), Positive family history (51%), Myopic correction worse than −1.0DS (22%), worse than −3.0DS (10%), and disc haemorrhage at baseline examination (7%).
Conclusion: Early baseline data shows a heterogeneous cohort representing the full range of suspects and early manifest glaucoma patients seen in day-to-day clinics, in a study that will recruit adequate numbers to assess predictors of progression in glaucoma suspects.
Method: Prospective, observational cohort study, recruiting glaucoma suspects based on disc appearance or ocular hypertension, and early manifest glaucoma (EMG) patients with early field loss, (mean deviation better than −5.0 dB).
Results: Initial data for 304 patients, (48.7%) EMG and (51.3%) glaucoma suspects.
Mean age 66.0(+/− 9.7) yrs, mean vertical cup:disc ratio (VCDR) 0.67(+/−0.12), mean IOP 16.10(+/− 3.6) mmHg, mean CCT 543(+/−34) μm.
Average visual field mean deviation −0.87(+/− 1.68) dB.
Comparison of EMG and suspect cohorts suggest higher VCDR, thinner CCT and worse visual field mean deviation in early manifest group, with no difference in IOP.
114 patients (37.5%) currently on medical therapy, 72% using a sole agent, prostaglandin analogue (83%), beta blocker (16%).
64 patients (21%) have had SLT, 31 of these also currently on drops.
Prevalence of risk factors in the study cohort; Migraines (14%), Raynauds phenomenon (5%), Cardiovascular disease (13%), Positive family history (51%), Myopic correction worse than −1.0DS (22%), worse than −3.0DS (10%), and disc haemorrhage at baseline examination (7%).
Conclusion: Early baseline data shows a heterogeneous cohort representing the full range of suspects and early manifest glaucoma patients seen in day-to-day clinics, in a study that will recruit adequate numbers to assess predictors of progression in glaucoma suspects.
| Original language | English |
|---|---|
| Article number | P20 |
| Pages (from-to) | 81-81 |
| Number of pages | 1 |
| Journal | Clinical and Experimental Ophthalmology |
| Volume | 41 |
| Issue number | Supplement 1 |
| Publication status | Published - Nov 2013 |