Baseline data of patients enrolled in PROGRESSA study

glaucoma suspect and early manifest glaucoma progression trial

Jude Fitzgerald, Bronwyn Usher, Jamie Craig, John Landers, Robert Casson, Stuart Graham, Ashish Agar, Paul Healey

Research output: Contribution to journalMeeting abstract

Abstract

Purpose: To report baseline data and methodology for initial cohort of patients recruited to PROGRESSA (Predicting Risk Of Glaucoma : RElevant SNPs with Strong Association) study, aiming to develop predictors of progression for the full range of glaucoma suspects and early glaucoma patients including genetic risk profiling.

Method: Prospective, observational cohort study, recruiting glaucoma suspects based on disc appearance or ocular hypertension, and early manifest glaucoma (EMG) patients with early field loss, (mean deviation better than −5.0 dB).

Results: Initial data for 304 patients, (48.7%) EMG and (51.3%) glaucoma suspects.

Mean age 66.0(+/− 9.7) yrs, mean vertical cup:disc ratio (VCDR) 0.67(+/−0.12), mean IOP 16.10(+/− 3.6) mmHg, mean CCT 543(+/−34) μm.

Average visual field mean deviation −0.87(+/− 1.68) dB.

Comparison of EMG and suspect cohorts suggest higher VCDR, thinner CCT and worse visual field mean deviation in early manifest group, with no difference in IOP.

114 patients (37.5%) currently on medical therapy, 72% using a sole agent, prostaglandin analogue (83%), beta blocker (16%).

64 patients (21%) have had SLT, 31 of these also currently on drops.

Prevalence of risk factors in the study cohort; Migraines (14%), Raynauds phenomenon (5%), Cardiovascular disease (13%), Positive family history (51%), Myopic correction worse than −1.0DS (22%), worse than −3.0DS (10%), and disc haemorrhage at baseline examination (7%).

Conclusion: Early baseline data shows a heterogeneous cohort representing the full range of suspects and early manifest glaucoma patients seen in day-to-day clinics, in a study that will recruit adequate numbers to assess predictors of progression in glaucoma suspects.
Original languageEnglish
Article numberP20
Pages (from-to)81-81
Number of pages1
JournalClinical and Experimental Ophthalmology
Volume41
Issue numberSupplement 1
DOIs
Publication statusPublished - Nov 2013

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