Baseline data of patients enrolled in PROGRESSA study: glaucoma suspect and early manifest glaucoma progression trial

Jude Fitzgerald, Bronwyn Usher, Jamie Craig, John Landers, Robert Casson, Stuart Graham, Ashish Agar, Paul Healey

Research output: Contribution to journalMeeting abstract

Abstract

Purpose: To report baseline data and methodology for initial cohort of patients recruited to PROGRESSA (Predicting Risk Of Glaucoma : RElevant SNPs with Strong Association) study, aiming to develop predictors of progression for the full range of glaucoma suspects and early glaucoma patients including genetic risk profiling.

Method: Prospective, observational cohort study, recruiting glaucoma suspects based on disc appearance or ocular hypertension, and early manifest glaucoma (EMG) patients with early field loss, (mean deviation better than −5.0 dB).

Results: Initial data for 304 patients, (48.7%) EMG and (51.3%) glaucoma suspects.

Mean age 66.0(+/− 9.7) yrs, mean vertical cup:disc ratio (VCDR) 0.67(+/−0.12), mean IOP 16.10(+/− 3.6) mmHg, mean CCT 543(+/−34) μm.

Average visual field mean deviation −0.87(+/− 1.68) dB.

Comparison of EMG and suspect cohorts suggest higher VCDR, thinner CCT and worse visual field mean deviation in early manifest group, with no difference in IOP.

114 patients (37.5%) currently on medical therapy, 72% using a sole agent, prostaglandin analogue (83%), beta blocker (16%).

64 patients (21%) have had SLT, 31 of these also currently on drops.

Prevalence of risk factors in the study cohort; Migraines (14%), Raynauds phenomenon (5%), Cardiovascular disease (13%), Positive family history (51%), Myopic correction worse than −1.0DS (22%), worse than −3.0DS (10%), and disc haemorrhage at baseline examination (7%).

Conclusion: Early baseline data shows a heterogeneous cohort representing the full range of suspects and early manifest glaucoma patients seen in day-to-day clinics, in a study that will recruit adequate numbers to assess predictors of progression in glaucoma suspects.
Original languageEnglish
Article numberP20
Pages (from-to)81-81
Number of pages1
JournalClinical and Experimental Ophthalmology
Volume41
Issue numberSupplement 1
Publication statusPublished - Nov 2013

Cite this