Bcl11b-A critical neurodevelopmental transcription factor-roles in health and disease

Matthew J. Lennon, Simon P. Jones, Michael D. Lovelace, Gilles J. Guillemin, Bruce J. Brew*

*Corresponding author for this work

Research output: Contribution to journalReview article

11 Citations (Scopus)
4 Downloads (Pure)

Abstract

B cell leukemia 11b (Bcl11b) is a zinc finger protein transcription factor with a multiplicity of functions. It works as both a genetic suppressor and activator, acting directly, attaching to promoter regions, as well as indirectly, attaching to promoter-bound transcription factors. Bcl11b is a fundamental transcription factor in fetal development, with important roles for the differentiation and development of various neuronal subtypes in the central nervous system (CNS). It has been used as a specific marker of layer V subcerebral projection neurons as well as striatal interneurons. Bcl11b also has critical developmental functions in the immune, integumentary and cardiac systems, to the extent that Bcl11b knockout mice are incompatible with extra-uterine life. Bcl11b has been implicated in a number of disease states including Huntington’s disease, Alzheimer’s disease, HIV and T-Cell malignancy, amongst others. Bcl11b is a fascinating protein whose critical roles in the CNS and other parts of the body are yet to be fully explicated. This review summarizes the current literature on Bcl11b and its functions in development, health, and disease as well as future directions for research.

Original languageEnglish
Article number89
Pages (from-to)1-7
Number of pages7
JournalFrontiers in Cellular Neuroscience
Volume11
DOIs
Publication statusPublished - 29 Mar 2017

Keywords

  • BCL11B
  • Ctip
  • neurodevelopment
  • Huntingtons disease
  • Alzheimers disease
  • BDNF

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