BDNF genetic variants are associated with onset age of familial Parkinson disease

GenePD Study

S. Karamohamed, J. C. Latourelle, B. A. Racette, J. S. Perlmutter, G. F. Wooten, M. Lew, C. Klein, H. Shill, L. I. Golbe, M. H. Mark, M. Guttman, G. Nicholson, J. B. Wilk, M. Saint-Hilaire, A. L. DeStefano, R. Prakash, S. Tobin, J. Williamson, O. Suchowersky, N. Labell & 16 others B. N.J. Growdon, C. Singer, R. Watts, S. Goldwurm, G. Pezzoli, K. B. Baker, M. L. Giroux, P. P. Pramstaller, D. J. Burn, P. Chinnery, S. Sherman, P. Vieregge, I. Litvan, J. F. Gusella, R. H. Myers, A. Parsian*

*Corresponding author for this work

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age.

Original languageEnglish
Pages (from-to)1823-1825
Number of pages3
JournalNeurology
Volume65
Issue number11
DOIs
Publication statusPublished - Dec 2005
Externally publishedYes

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    Karamohamed, S., Latourelle, J. C., Racette, B. A., Perlmutter, J. S., Wooten, G. F., Lew, M., ... Parsian, A. (2005). BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study. Neurology, 65(11), 1823-1825. https://doi.org/10.1212/01.wnl.0000187075.81589.fd