Beta adrenergic blockade reduces utilitarian judgement

Terbeck Sylvia*, Kahane Guy, McTavish Sarah, Savulescu Julian, Levy Neil, Hewstone Miles, Philip J. Cowen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)
14 Downloads (Pure)

Abstract

Noradrenergic pathways are involved in mediating the central and peripheral effects of physiological arousal. The aim of the present study was to investigate the role of noradrenergic transmission in moral decision-making. We studied the effects in healthy volunteers of propranolol (a noradrenergic beta-adrenoceptor antagonist) on moral judgement in a set of moral dilemmas pitting utilitarian outcomes (e.g., saving five lives) against highly aversive harmful actions (e.g., killing an innocent person) in a double-blind, placebo-controlled, parallel group design. Propranolol (40. mg orally) significantly reduced heart rate, but had no effect on self-reported mood. Importantly, propranolol made participants more likely to judge harmful actions as morally unacceptable, but only in dilemmas where harms were 'up close and personal'. In addition, longer response times for such personal dilemmas were only found for the placebo group. Finally, judgments in personal dilemmas by the propranolol group were more decisive. These findings indicate that noradrenergic pathways play a role in responses to moral dilemmas, in line with recent work implicating emotion in moral decision-making. However, contrary to current theorising, these findings also suggest that aversion to harming is not driven by emotional arousal. Our findings are also of significant practical interest given that propranolol is a widely used drug in different settings, and is currently being considered as a potential treatment for post-traumatic stress disorder in military and rescue service personnel.

Original languageEnglish
Pages (from-to)323-328
Number of pages6
JournalBiological Psychology
Volume92
Issue number2
DOIs
Publication statusPublished - Feb 2013
Externally publishedYes

Bibliographical note

Copyright the Publisher 2012. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Corrigendum can be found at Biological Psychology volume 103, p 370, https://doi.org/10.1016/j.biopsycho.2014.11.007 and Biological Psychology volume 97, p67, https://doi.org/10.1016/j.biopsycho.2013.12.010

Keywords

  • moral decision-making
  • noradrenaline
  • propranolol
  • utilitarian judgement

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