Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

Judith Miklossy; Hong Qing; Aleksandra Radenovic; Andras Kis; Bertrand Vileno; Forró Làszló; Lisa Miller; Ralph N. Martins; Gerard Waeber; Vincent Mooser; Fred Bosman; Kamel Khalili; Nune Darbinian; Patrick L. McGeer

doi:10.1016/j.neurobiolaging.2008.08.019

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

Judith Miklossy^*, Hong Qing, Aleksandra Radenovic, Andras Kis, Bertrand Vileno, Forró Làszló, Lisa Miller, Ralph N. Martins, Gerard Waeber, Vincent Mooser, Fred Bosman, Kamel Khalili, Nune Darbinian, Patrick L. McGeer

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

176 Citations (Scopus)

Abstract

Strong epidemiologic evidence suggests an association between Alzheimer disease (AD) and type 2 diabetes. To determine if amyloid beta (Aβ) and hyperphosphorylated tau occurs in type 2 diabetes, pancreas tissues from 21 autopsy cases (10 type 2 diabetes and 11 controls) were analyzed. APP and tau mRNAs were identified in human pancreas and in cultured insulinoma beta cells (INS-1) by RT-PCR. Prominent APP and tau bands were detected by Western blotting in pancreatic extracts. Aggregated Aβ, hyperphosphorylated tau, ubiquitin, apolipoprotein E, apolipoprotein(a), IB1/JIP-1 and JNK1 were detected in Langerhans islets in type 2 diabetic patients. Aβ was co-localized with amylin in islet amyloid deposits. In situ beta sheet formation of islet amyloid deposits was shown by infrared microspectroscopy (SIRMS). LPS increased APP in non-neuronal cells as well. We conclude that Aβ deposits and hyperphosphorylated tau are also associated with type 2 diabetes, highlighting common pathogenetic features in neurodegenerative disorders, including AD and type 2 diabetes and suggesting that Aβ deposits and hyperphosphorylated tau may also occur in other organs than the brain.

Original language	English
Pages (from-to)	1503-1515
Number of pages	13
Journal	Neurobiology of Aging
Volume	31
Issue number	9
DOIs	https://doi.org/10.1016/j.neurobiolaging.2008.08.019
Publication status	Published - Sept 2010
Externally published	Yes

Keywords

Alzheimer's disease
Amylin
Apolipoprotein-a
Apolipoprotein-E
APP
Beta amyloid
IB1/JIP-1
JNK-1
LPS
Tau
Type 2 diabetes
Ubiquitin

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10.1016/j.neurobiolaging.2008.08.019

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title = "Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes",

abstract = "Strong epidemiologic evidence suggests an association between Alzheimer disease (AD) and type 2 diabetes. To determine if amyloid beta (Aβ) and hyperphosphorylated tau occurs in type 2 diabetes, pancreas tissues from 21 autopsy cases (10 type 2 diabetes and 11 controls) were analyzed. APP and tau mRNAs were identified in human pancreas and in cultured insulinoma beta cells (INS-1) by RT-PCR. Prominent APP and tau bands were detected by Western blotting in pancreatic extracts. Aggregated Aβ, hyperphosphorylated tau, ubiquitin, apolipoprotein E, apolipoprotein(a), IB1/JIP-1 and JNK1 were detected in Langerhans islets in type 2 diabetic patients. Aβ was co-localized with amylin in islet amyloid deposits. In situ beta sheet formation of islet amyloid deposits was shown by infrared microspectroscopy (SIRMS). LPS increased APP in non-neuronal cells as well. We conclude that Aβ deposits and hyperphosphorylated tau are also associated with type 2 diabetes, highlighting common pathogenetic features in neurodegenerative disorders, including AD and type 2 diabetes and suggesting that Aβ deposits and hyperphosphorylated tau may also occur in other organs than the brain.",

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AU - Qing, Hong

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AU - Kis, Andras

AU - Vileno, Bertrand

AU - Làszló, Forró

AU - Miller, Lisa

AU - Martins, Ralph N.

AU - Waeber, Gerard

AU - Mooser, Vincent

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AU - Khalili, Kamel

AU - Darbinian, Nune

AU - McGeer, Patrick L.

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KW - JNK-1

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KW - Ubiquitin

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Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

Abstract

Keywords

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