Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

Judith Miklossy*, Hong Qing, Aleksandra Radenovic, Andras Kis, Bertrand Vileno, Forró Làszló, Lisa Miller, Ralph N. Martins, Gerard Waeber, Vincent Mooser, Fred Bosman, Kamel Khalili, Nune Darbinian, Patrick L. McGeer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

137 Citations (Scopus)

Abstract

Strong epidemiologic evidence suggests an association between Alzheimer disease (AD) and type 2 diabetes. To determine if amyloid beta (Aβ) and hyperphosphorylated tau occurs in type 2 diabetes, pancreas tissues from 21 autopsy cases (10 type 2 diabetes and 11 controls) were analyzed. APP and tau mRNAs were identified in human pancreas and in cultured insulinoma beta cells (INS-1) by RT-PCR. Prominent APP and tau bands were detected by Western blotting in pancreatic extracts. Aggregated Aβ, hyperphosphorylated tau, ubiquitin, apolipoprotein E, apolipoprotein(a), IB1/JIP-1 and JNK1 were detected in Langerhans islets in type 2 diabetic patients. Aβ was co-localized with amylin in islet amyloid deposits. In situ beta sheet formation of islet amyloid deposits was shown by infrared microspectroscopy (SIRMS). LPS increased APP in non-neuronal cells as well. We conclude that Aβ deposits and hyperphosphorylated tau are also associated with type 2 diabetes, highlighting common pathogenetic features in neurodegenerative disorders, including AD and type 2 diabetes and suggesting that Aβ deposits and hyperphosphorylated tau may also occur in other organs than the brain.

Original languageEnglish
Pages (from-to)1503-1515
Number of pages13
JournalNeurobiology of Aging
Volume31
Issue number9
DOIs
Publication statusPublished - Sep 2010
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Amylin
  • Apolipoprotein-a
  • Apolipoprotein-E
  • APP
  • Beta amyloid
  • IB1/JIP-1
  • JNK-1
  • LPS
  • Tau
  • Type 2 diabetes
  • Ubiquitin

Fingerprint

Dive into the research topics of 'Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes'. Together they form a unique fingerprint.

Cite this