Beyond the discovery void

New targets for antibacterial compounds

Claire E. Broughton, Hugo A. Van Den Berg, Alan M. Wemyss, David I. Roper, Alison Rodger

Research output: Contribution to journalArticle

2 Citations (Scopus)
1 Downloads (Pure)

Abstract

Antibiotics save many lives, but their efficacy is under threat: overprescription, populationgrowth, and global travel all contribute to the rapid origination and spread of resistantstrains. Exacerbating this threat is the fact that no new major classes of antibioticshave been discovered in the last 30 years: this is the “discovery void.” We discuss thetraditional molecular targets of antibiotics as well as putative novel targets.

Original languageEnglish
Pages (from-to)153-182
Number of pages30
JournalScience Progress
Volume99
Issue number2
DOIs
Publication statusPublished - 1 Jun 2016
Externally publishedYes

Keywords

  • Antibiotics
  • Bacterial resistances to antibiotics
  • Cell division
  • Cellwall
  • Discovery void
  • MRSA

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