bFGF enhances the development of the collateral circulation after acute arterial occlusion

JO Chleboun*, RN Martins, CA Mitchell, TV Chirila

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)

Abstract

An adequate collateral circulation is crucial to tissue survival subsequent to proximal major arterial occlusion. The precise mechanism of collateral blood vessel development and the biochemical mediators involved in this process are unknown. To evaluate the influence of a number of agents on the development of the collateral circulation, we developed a rat model of severe hind limb ischaemia. The recovery of blood flow after acute arterial occlusion was increased by exogenous basic fibroblast growth factor and heparin, and decreased by protamine. Erucamide (cis-13-docosenamide), an angiogenic lipid, had no effect on collateral blood flow. These results indicate that basic fibroblast growth factor and heparin are potential therapeutic agents in the treatment of peripheral vascular disease.

Original languageEnglish
Pages (from-to)510-516
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume185
Issue number2
DOIs
Publication statusPublished - 15 Jun 1992
Externally publishedYes

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