Bilateral auditory ossicular expansions in a child with beta-thalassemia major: case report and literature review

Melisha Sirisena*, Catherine S. Birman, Amy J. McKibbin, Katie J. O'Brien

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Marrow proliferation of the ossicular chain is a rare phenomenon. To date, only two other cases have described this rarity. We report a third paediatric case from Australia. A seven-year-old with thalassemia major demonstrated conductive impairment during surveillance for Deferasirox ototoxicity. Otitis media was assumed, however, CT scan of the petrous temporal bone revealed extramedullary haematopoiesis causing bilateral ossicular expansions and fixed conductive deficit. Reports of hearing loss in the thalassemia population focus on sensorineural impairment from iron chelation therapies. Clinicians should suspect ossicular deformation where treatment has been delayed, poorly controlled or conductive deficit persists without effusion.

Original languageEnglish
Pages (from-to)126-131
Number of pages6
JournalInternational Journal of Pediatric Otorhinolaryngology
Volume112
DOIs
Publication statusPublished - 1 Sep 2018
Externally publishedYes

Keywords

  • Blood transfusion
  • Conductive hearing loss
  • Extramedullary haematopoiesis
  • Iron chelation therapy
  • Ototoxicity
  • Paediatric

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