Bilateral neovascular age-related macular degeneration: comparisons between first and second eyes

Jamie K. Chew, Meidong Zhu, Geoffrey K. Broadhead, Kehui Luo, Thomas Hong, Andrew A. Chang*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    16 Citations (Scopus)

    Abstract

    Purpose: To compare 12-month outcomes and clinical presentations between first and second eyes of patients who developed neovascular age-related macular degeneration (nAMD) in both eyes and received ranibizumab intravitreal therapy (IVT). Methods: This is a retrospective case series of 45 patients undergoing IVT for unilateral nAMD who subsequently developed second-eye nAMD. At each visit, both eyes underwent visual acuity (VA) measurement and optical coherence tomography (OCT). Results: In second eyes, 53% were asymptomatic at baseline, with OCT retinal fluid as the only sign of nAMD among 33% of patients. In eyes with baseline VA >6/9, 82% of second treated eyes maintained this vision versus 12% of first eyes (p = 0.05). At 12 months, 70% of second eyes were fluid free versus 41% of first eyes (p = 0.02). Conclusions: A large proportion of patients are asymptomatic at diagnosis of second-eye nAMD. Early intervention following earlier detection of nAMD in the second eye may lead to improved clinical outcomes.

    Original languageEnglish
    Pages (from-to)23-30
    Number of pages8
    JournalOphthalmologica
    Volume238
    Issue number1-2
    DOIs
    Publication statusPublished - Aug 2017

    Keywords

    • macular degeneration
    • anti-vascular endothelial growth factor
    • choroidal neovascularization
    • neovascular eye disease

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