TY - JOUR
T1 - Bilateral orbitomedial leucotomy for obsessive-compulsive disorder
T2 - A single-case study using positron emission tomography
AU - Sachdev, P.
AU - Trollor, J.
AU - Walker, A.
AU - Wen, W.
AU - Fulham, M.
AU - Smith, J. S.
AU - Matheson, J.
PY - 2001
Y1 - 2001
N2 - Objective: The objective of this report is to correlate the clinical outcome of neurosurgery for obsessive-compulsive disorder (OCD) with regional cerebral glucose metabolic changes. Clinical picture: The patient was a 37-year-old female patient with severe and intractable OCD. Treatment: The patient was treated with bilateral stereotactic lesions in the frontal white matter superior to the orbito-medial cortex. Outcome: She had a remarkable improvement in her obsessive-compulsive symptoms, which was sustained up to 3 years of follow up. A positron emission tomography (PET) scan performed 18 days after surgery demonstrated an obvious reduction of metabolism in the caudate head, anterior cingulate and orbital, medial and lateral prefrontal cortices and the thalamus. At 1 year postsurgery, metabolic rate was still reduced in the anterior cingulate gyrus, caudate and thalamus compared with preoperative baseline. The patient demonstrated no long-term cognitive effects of the surgery. Conclusions: This case supports some of the cortical-subcortical circuit dysfunction models of OCD and argues for the further evaluation of neurosurgery for the treatment of a severe and intractable disorder.
AB - Objective: The objective of this report is to correlate the clinical outcome of neurosurgery for obsessive-compulsive disorder (OCD) with regional cerebral glucose metabolic changes. Clinical picture: The patient was a 37-year-old female patient with severe and intractable OCD. Treatment: The patient was treated with bilateral stereotactic lesions in the frontal white matter superior to the orbito-medial cortex. Outcome: She had a remarkable improvement in her obsessive-compulsive symptoms, which was sustained up to 3 years of follow up. A positron emission tomography (PET) scan performed 18 days after surgery demonstrated an obvious reduction of metabolism in the caudate head, anterior cingulate and orbital, medial and lateral prefrontal cortices and the thalamus. At 1 year postsurgery, metabolic rate was still reduced in the anterior cingulate gyrus, caudate and thalamus compared with preoperative baseline. The patient demonstrated no long-term cognitive effects of the surgery. Conclusions: This case supports some of the cortical-subcortical circuit dysfunction models of OCD and argues for the further evaluation of neurosurgery for the treatment of a severe and intractable disorder.
KW - Frontal-subcortical circuits
KW - Leucotomy
KW - Neurosurgery
KW - Obsessive-compulsive disorder
KW - Positron emission tomography
UR - http://www.scopus.com/inward/record.url?scp=0034757266&partnerID=8YFLogxK
U2 - 10.1046/j.1440-1614.2001.00941.x
DO - 10.1046/j.1440-1614.2001.00941.x
M3 - Article
C2 - 11551286
AN - SCOPUS:0034757266
SN - 0004-8674
VL - 35
SP - 684
EP - 690
JO - Australian and New Zealand Journal of Psychiatry
JF - Australian and New Zealand Journal of Psychiatry
IS - 5
ER -