Bioactive natural products from Papua New Guinea marine sponges

Jeffery C. Noro*, John A. Kalaitzis, Brett A. Neilan

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

15 Citations (Scopus)

Abstract

The discovery of novel natural products for drug development relies heavily upon a rich biodiversity, of which the marine environment is an obvious example. Marine natural product research has spawned several drugs and many other candidates, some of which are the focus of current clinical trials. The sponge megadiversity of Papua New Guinea is a rich but underexplored source of bioactive natural products. Here, we review some of the many natural products derived from PNG sponges with an emphasis on those with interesting biological activity and, therefore, drug potential. Many bioactive natural products discussed here appear to be derived from non-ribosomal peptide and polyketide biosynthesis pathways, strongly suggesting a microbial origin of these compounds. With this in mind, we also explore the notion of sponge-symbiont biosynthesis of these bioactive compounds and present examples to support the working hypothesis.

Original languageEnglish
Pages (from-to)2077-2095
Number of pages19
JournalChemistry and Biodiversity
Volume9
Issue number10
DOIs
Publication statusPublished - Oct 2012
Externally publishedYes

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