Biocompatible graphene oxide-based glucose biosensors

Yong Liu*, Dingshan Yu, Chao Zeng, Zongcheng Miao, Liming Dai

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

577 Citations (Scopus)


This letter demonstrates that a novel, highly efficient enzyme electrode can be directly obtained using covalent attachment between carboxyl acid groups of graphene oxide sheets and amines of glucose oxidase. The resulting biosensor exhibits a broad linear range up to 28 mM·mm-2 glucose with a sensitivity of 8.045 mA·cm-2·M-1. The glucose oxidase-immobilized graphene oxide electrode also shows a reproducibility and a good storage stability, suggesting potentials for a wide range of practical applications. The biocompatibility of as-synthesized graphene oxide nanosheets with human cells, especially retinal pigment epithelium (RPE) cells, was investigated for the first time in the present work. Microporous graphene oxide exhibits good biocompatibility and has potential advantages with respect to cell attachment and proliferation, leading to opportunities for using graphene-based biosensors for the clinical diagnosis.

Original languageEnglish
Pages (from-to)6158-6160
Number of pages3
Issue number9
Publication statusPublished - 4 May 2010


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