Biodegradable polymer versus second-generation durable polymer drug-eluting stents in patients with coronary artery disease: a meta-analysis

James J. Wu, Joshua A. H. Way, Probal Roy, Andy Yong, Harry Lowe, Leonard Kritharides, David Brieger*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
7 Downloads (Pure)


Aims: Biodegradable polymer drug-eluting stents (BP-DES) were developed in hopes of reducing the risk of stent thrombosis. The comparison of this new stent platform with second-generation durable polymer drug-eluting stents (DP-DES) has not been well described. We, therefore, performed a meta-analysis to evaluate the safety and efficacy profiles of BP-DES versus second-generation DP-DES in patients with coronary artery disease. Methods and Results: Electronic database searches were conducted, from their dates of inception to June 2018, to identify randomized controlled trials (RCTs) comparing patients with either BP-DES or second-generation DP-DES. Risk estimates were expressed as risk ratios (RRs) with 95% confidence intervals (CIs). We also performed a landmark analysis beyond 1 year and sensitivity analyses based on different variables. A total of 24,406 patients from 19 RCTs were included in the present meta-analysis. There were no significant differences between BP-DES and second-generation DP-DES for the risks of definite or probable stent thrombosis (RR 0.88; 95% CI, 0.69–1.12; P = 0.29), myocardial infarction (RR 0.97; 95% CI, 0.86–1.09; P = 0.59), cardiac death (RR 1.08; 95% CI, 0.92–1.28; P = 0.34), all-cause death (RR 1.02; 95% CI, 0.91–1.13; P = 0.77), target lesion revascularization (RR 1.05; 95% CI, 0.94–1.17; P = 0.38), and target vessel revascularization (RR 1.05; 95% CI, 0.95–1.16; P = 0.36). Similar outcomes were observed regardless of anti-proliferative drug and duration of dual antiplatelet therapy (all P > 0.05). Conclusion: Our findings demonstrate similar safety and efficacy profiles between BP-DES and second-generation BP-DES, with comparable rates of stent thrombosis.

Original languageEnglish
Article numbere93
Pages (from-to)1-10
Number of pages10
JournalHealth Science Reports
Issue number11
Publication statusPublished - 1 Nov 2018
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.


  • biodegradable polymer
  • coronary artery disease
  • drug-eluting stents
  • durable polymer
  • meta-analysis


Dive into the research topics of 'Biodegradable polymer versus second-generation durable polymer drug-eluting stents in patients with coronary artery disease: a meta-analysis'. Together they form a unique fingerprint.

Cite this