TY - JOUR
T1 - Biodegradation of the ZnO
T2 - Eu nanoparticles in the tissues of adult mouse after alimentary application
AU - Kielbik, Paula
AU - Kaszewski, Jaroslaw
AU - Rosowska, Julita
AU - Wolska, Ewelina
AU - Witkowski, Bartłomiej S.
AU - Gralak, Mikolaj A.
AU - Gajewski, Zdzisław
AU - Godlewski, Marek
AU - Godlewski, Michal M.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Biodegradable zinc oxide nanoparticles (ZnO NPs) are considered promising materials for future biomedical applications. To fulfil this potential, biodistribution and elimination patterns of ZnO NPs in the living organism need to be resolved. In order to investigate gastrointestinal absorption of ZnO NPs and their intra-organism distribution, water suspension of ZnO or fluorescent ZnO:Eu (Europium-doped zinc oxide) NPs (10 mg/ml; 0.3 ml/mouse) was alimentary-administered (IG: intra-gastric) to adult mice. Internal organs collected at key time-points after IG were evaluated by AAS for Zn concentration and analysed by cytometric techniques. We found that Zn-based NPs were readily absorbed and distributed (3 h post IG) in the nanoparticle form throughout the organism. Results suggest, that liver and kidneys were key organs responsible for NPs elimination, while accumulation was observed in the spleen and adipose tissues. We also showed that ZnO/ZnO:Eu NPs were able to cross majority of biological barriers in the organism (including blood–brain-barrier).
AB - Biodegradable zinc oxide nanoparticles (ZnO NPs) are considered promising materials for future biomedical applications. To fulfil this potential, biodistribution and elimination patterns of ZnO NPs in the living organism need to be resolved. In order to investigate gastrointestinal absorption of ZnO NPs and their intra-organism distribution, water suspension of ZnO or fluorescent ZnO:Eu (Europium-doped zinc oxide) NPs (10 mg/ml; 0.3 ml/mouse) was alimentary-administered (IG: intra-gastric) to adult mice. Internal organs collected at key time-points after IG were evaluated by AAS for Zn concentration and analysed by cytometric techniques. We found that Zn-based NPs were readily absorbed and distributed (3 h post IG) in the nanoparticle form throughout the organism. Results suggest, that liver and kidneys were key organs responsible for NPs elimination, while accumulation was observed in the spleen and adipose tissues. We also showed that ZnO/ZnO:Eu NPs were able to cross majority of biological barriers in the organism (including blood–brain-barrier).
KW - ZnO:Eu
KW - nanoparticles
KW - blood–organ barriers
KW - nanoparticle circulation
KW - biodegradation
UR - http://www.scopus.com/inward/record.url?scp=85013660884&partnerID=8YFLogxK
U2 - 10.1016/j.nano.2016.11.002
DO - 10.1016/j.nano.2016.11.002
M3 - Article
C2 - 27884640
AN - SCOPUS:85013660884
VL - 13
SP - 843
EP - 852
JO - Nanomedicine: Nanotechnology, Biology, and Medicine
JF - Nanomedicine: Nanotechnology, Biology, and Medicine
SN - 1549-9634
IS - 3
ER -