Abstract
In recent years, the practical application of protein-based nanoparticles (PNPs) has expanded rapidly into areas like drug delivery, vaccine development, and biocatalysis. PNPs possess unique features that make them attractive as potential platforms for a variety of nanobiotechnological applications. They self-assemble from multiple protein subunits into hollow monodisperse structures; they are highly stable, biocompatible, and biodegradable; and their external components and encapsulation properties can be readily manipulated by chemical or genetic strategies. Moreover, their complex and perfect symmetry have motivated researchers to mimic their properties in order to create de novo protein assemblies. This review focuses on recent advances in the bioengineering and bioconjugation of PNPs and the implementation of synthetic biology concepts to exploit and enhance PNP’s intrinsic properties and to impart them with novel functionalities.
| Language | English |
|---|---|
| Article number | 370 |
| Pages | 1-30 |
| Number of pages | 30 |
| Journal | Genes |
| Volume | 9 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 23 Jul 2018 |
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Bibliographical note
Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.Cite this
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Bioengineering strategies for protein-based nanoparticles. / Diaz, Dennis; Care, Andrew; Sunna, Anwar.
In: Genes, Vol. 9, No. 7, 370, 23.07.2018, p. 1-30.Research output: Contribution to journal › Review article › Research › peer-review
TY - JOUR
T1 - Bioengineering strategies for protein-based nanoparticles
AU - Diaz,Dennis
AU - Care,Andrew
AU - Sunna,Anwar
N1 - Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.
PY - 2018/7/23
Y1 - 2018/7/23
N2 - In recent years, the practical application of protein-based nanoparticles (PNPs) has expanded rapidly into areas like drug delivery, vaccine development, and biocatalysis. PNPs possess unique features that make them attractive as potential platforms for a variety of nanobiotechnological applications. They self-assemble from multiple protein subunits into hollow monodisperse structures; they are highly stable, biocompatible, and biodegradable; and their external components and encapsulation properties can be readily manipulated by chemical or genetic strategies. Moreover, their complex and perfect symmetry have motivated researchers to mimic their properties in order to create de novo protein assemblies. This review focuses on recent advances in the bioengineering and bioconjugation of PNPs and the implementation of synthetic biology concepts to exploit and enhance PNP’s intrinsic properties and to impart them with novel functionalities.
AB - In recent years, the practical application of protein-based nanoparticles (PNPs) has expanded rapidly into areas like drug delivery, vaccine development, and biocatalysis. PNPs possess unique features that make them attractive as potential platforms for a variety of nanobiotechnological applications. They self-assemble from multiple protein subunits into hollow monodisperse structures; they are highly stable, biocompatible, and biodegradable; and their external components and encapsulation properties can be readily manipulated by chemical or genetic strategies. Moreover, their complex and perfect symmetry have motivated researchers to mimic their properties in order to create de novo protein assemblies. This review focuses on recent advances in the bioengineering and bioconjugation of PNPs and the implementation of synthetic biology concepts to exploit and enhance PNP’s intrinsic properties and to impart them with novel functionalities.
KW - protein-based nanoparticles
KW - bioengineering
KW - nanobiotechnology
KW - synthetic biology
KW - biomedicine
KW - biocatalysis
KW - virus-like particle
KW - nanocages
UR - http://www.scopus.com/inward/record.url?scp=85050954097&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/arc/CE140100003
U2 - 10.3390/genes9070370
DO - 10.3390/genes9070370
M3 - Review article
VL - 9
SP - 1
EP - 30
JO - Genes
T2 - Genes
JF - Genes
SN - 2073-4425
IS - 7
M1 - 370
ER -