Bioengineering strategies for protein-based nanoparticles

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

In recent years, the practical application of protein-based nanoparticles (PNPs) has expanded rapidly into areas like drug delivery, vaccine development, and biocatalysis. PNPs possess unique features that make them attractive as potential platforms for a variety of nanobiotechnological applications. They self-assemble from multiple protein subunits into hollow monodisperse structures; they are highly stable, biocompatible, and biodegradable; and their external components and encapsulation properties can be readily manipulated by chemical or genetic strategies. Moreover, their complex and perfect symmetry have motivated researchers to mimic their properties in order to create de novo protein assemblies. This review focuses on recent advances in the bioengineering and bioconjugation of PNPs and the implementation of synthetic biology concepts to exploit and enhance PNP’s intrinsic properties and to impart them with novel functionalities.

LanguageEnglish
Article number370
Pages1-30
Number of pages30
JournalGenes
Volume9
Issue number7
DOIs
Publication statusPublished - 23 Jul 2018

Fingerprint

Bioengineering
Nanoparticles
Proteins
Biocatalysis
Synthetic Biology
Protein Subunits
Vaccines
Research Personnel
Pharmaceutical Preparations

Bibliographical note

Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • protein-based nanoparticles
  • bioengineering
  • nanobiotechnology
  • synthetic biology
  • biomedicine
  • biocatalysis
  • virus-like particle
  • nanocages

Cite this

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title = "Bioengineering strategies for protein-based nanoparticles",
abstract = "In recent years, the practical application of protein-based nanoparticles (PNPs) has expanded rapidly into areas like drug delivery, vaccine development, and biocatalysis. PNPs possess unique features that make them attractive as potential platforms for a variety of nanobiotechnological applications. They self-assemble from multiple protein subunits into hollow monodisperse structures; they are highly stable, biocompatible, and biodegradable; and their external components and encapsulation properties can be readily manipulated by chemical or genetic strategies. Moreover, their complex and perfect symmetry have motivated researchers to mimic their properties in order to create de novo protein assemblies. This review focuses on recent advances in the bioengineering and bioconjugation of PNPs and the implementation of synthetic biology concepts to exploit and enhance PNP’s intrinsic properties and to impart them with novel functionalities.",
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Bioengineering strategies for protein-based nanoparticles. / Diaz, Dennis; Care, Andrew; Sunna, Anwar.

In: Genes, Vol. 9, No. 7, 370, 23.07.2018, p. 1-30.

Research output: Contribution to journalReview articleResearchpeer-review

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AU - Diaz, Dennis

AU - Care, Andrew

AU - Sunna, Anwar

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AB - In recent years, the practical application of protein-based nanoparticles (PNPs) has expanded rapidly into areas like drug delivery, vaccine development, and biocatalysis. PNPs possess unique features that make them attractive as potential platforms for a variety of nanobiotechnological applications. They self-assemble from multiple protein subunits into hollow monodisperse structures; they are highly stable, biocompatible, and biodegradable; and their external components and encapsulation properties can be readily manipulated by chemical or genetic strategies. Moreover, their complex and perfect symmetry have motivated researchers to mimic their properties in order to create de novo protein assemblies. This review focuses on recent advances in the bioengineering and bioconjugation of PNPs and the implementation of synthetic biology concepts to exploit and enhance PNP’s intrinsic properties and to impart them with novel functionalities.

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