Bioengineering strategies for protein-based nanoparticles

Dennis Diaz, Andrew Care, Anwar Sunna*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

69 Citations (Scopus)
245 Downloads (Pure)


In recent years, the practical application of protein-based nanoparticles (PNPs) has expanded rapidly into areas like drug delivery, vaccine development, and biocatalysis. PNPs possess unique features that make them attractive as potential platforms for a variety of nanobiotechnological applications. They self-assemble from multiple protein subunits into hollow monodisperse structures; they are highly stable, biocompatible, and biodegradable; and their external components and encapsulation properties can be readily manipulated by chemical or genetic strategies. Moreover, their complex and perfect symmetry have motivated researchers to mimic their properties in order to create de novo protein assemblies. This review focuses on recent advances in the bioengineering and bioconjugation of PNPs and the implementation of synthetic biology concepts to exploit and enhance PNP’s intrinsic properties and to impart them with novel functionalities.

Original languageEnglish
Article number370
Pages (from-to)1-30
Number of pages30
Issue number7
Publication statusPublished - 23 Jul 2018

Bibliographical note

Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.


  • protein-based nanoparticles
  • bioengineering
  • nanobiotechnology
  • synthetic biology
  • biomedicine
  • biocatalysis
  • virus-like particle
  • nanocages


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