Biological factors underpinning suicidal behaviour: an update

Maya N. Abou Chahla; Mahmoud I. Khalil; Stefano Comai; Lena Brundin; Sophie Erhardt; Gilles J. Guillemin

doi:10.3390/brainsci13030505

Biological factors underpinning suicidal behaviour: an update

Maya N. Abou Chahla^*, Mahmoud I. Khalil, Stefano Comai, Lena Brundin, Sophie Erhardt, Gilles J. Guillemin^*

^*Corresponding author for this work

Macquarie Medical School

Research output: Contribution to journal › Review article › peer-review

31 Citations (Scopus)

43 Downloads (Pure)

Abstract

Suicide, a global health burden, represents the 17th leading cause of death worldwide (1.3%), but the 4th among young people aged between 15 and 29 years of age, according to World Health Organization (WHO), 2019. Suicidal behaviour is a complex, multi-factorial, polygenic and independent mental health problem caused by a combination of alterations and dysfunctions of several biological pathways and disruption of normal mechanisms in brain regions that remain poorly understood and need further investigation to be deciphered. Suicide complexity and unpredictability gained international interest as a field of research. Several studies have been conducted at the neuropathological, inflammatory, genetic, and molecular levels to uncover the triggers behind suicidal behaviour and develop convenient and effective therapeutic or at least preventive procedures. This review aims to summarise and focus on current knowledge of diverse biological pathways involved in the neurobiology of suicidal behaviour, and briefly highlights future potential therapeutic pathways to prevent or even treat this significant public health problem.

Original language	English
Article number	505
Pages (from-to)	1-21
Number of pages	21
Journal	Brain Sciences
Volume	13
Issue number	3
DOIs	https://doi.org/10.3390/brainsci13030505
Publication status	Published - 16 Mar 2023

Bibliographical note

Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

epigenetics
hypothalamic-pituitary-adrenal axis
kynurenine pathway
neuroinflammation
psychiatric disorders
risk factors
suicidal ideation
suicide
suicide attempts

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10.3390/brainsci13030505Licence: CC BY

Publisher version (open access)Final published version, 2.73 MBLicence: CC BY

Cite this

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title = "Biological factors underpinning suicidal behaviour: an update",

abstract = "Suicide, a global health burden, represents the 17th leading cause of death worldwide (1.3\%), but the 4th among young people aged between 15 and 29 years of age, according to World Health Organization (WHO), 2019. Suicidal behaviour is a complex, multi-factorial, polygenic and independent mental health problem caused by a combination of alterations and dysfunctions of several biological pathways and disruption of normal mechanisms in brain regions that remain poorly understood and need further investigation to be deciphered. Suicide complexity and unpredictability gained international interest as a field of research. Several studies have been conducted at the neuropathological, inflammatory, genetic, and molecular levels to uncover the triggers behind suicidal behaviour and develop convenient and effective therapeutic or at least preventive procedures. This review aims to summarise and focus on current knowledge of diverse biological pathways involved in the neurobiology of suicidal behaviour, and briefly highlights future potential therapeutic pathways to prevent or even treat this significant public health problem.",

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AU - Khalil, Mahmoud I.

AU - Comai, Stefano

AU - Brundin, Lena

AU - Erhardt, Sophie

AU - Guillemin, Gilles J.

N1 - Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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Y1 - 2023/3/16

N2 - Suicide, a global health burden, represents the 17th leading cause of death worldwide (1.3%), but the 4th among young people aged between 15 and 29 years of age, according to World Health Organization (WHO), 2019. Suicidal behaviour is a complex, multi-factorial, polygenic and independent mental health problem caused by a combination of alterations and dysfunctions of several biological pathways and disruption of normal mechanisms in brain regions that remain poorly understood and need further investigation to be deciphered. Suicide complexity and unpredictability gained international interest as a field of research. Several studies have been conducted at the neuropathological, inflammatory, genetic, and molecular levels to uncover the triggers behind suicidal behaviour and develop convenient and effective therapeutic or at least preventive procedures. This review aims to summarise and focus on current knowledge of diverse biological pathways involved in the neurobiology of suicidal behaviour, and briefly highlights future potential therapeutic pathways to prevent or even treat this significant public health problem.

AB - Suicide, a global health burden, represents the 17th leading cause of death worldwide (1.3%), but the 4th among young people aged between 15 and 29 years of age, according to World Health Organization (WHO), 2019. Suicidal behaviour is a complex, multi-factorial, polygenic and independent mental health problem caused by a combination of alterations and dysfunctions of several biological pathways and disruption of normal mechanisms in brain regions that remain poorly understood and need further investigation to be deciphered. Suicide complexity and unpredictability gained international interest as a field of research. Several studies have been conducted at the neuropathological, inflammatory, genetic, and molecular levels to uncover the triggers behind suicidal behaviour and develop convenient and effective therapeutic or at least preventive procedures. This review aims to summarise and focus on current knowledge of diverse biological pathways involved in the neurobiology of suicidal behaviour, and briefly highlights future potential therapeutic pathways to prevent or even treat this significant public health problem.

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KW - neuroinflammation

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KW - risk factors

KW - suicidal ideation

KW - suicide

KW - suicide attempts

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DO - 10.3390/brainsci13030505

M3 - Review article

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ER -

Biological factors underpinning suicidal behaviour: an update

Abstract

Bibliographical note

Keywords

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