Biologically Active Metabolites from Xenorhabdus Spp., Part 2. Benzopyran-1-one Derivatives with Gastroprotective Activity

Bernie V. McInerney, Walter C. Taylor, Micheal J. Lacey, Raymond J. Akhurst, Richard P. Gregson

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153 Citations (Scopus)


Two novel antibiotic compounds, named xenocoumacins 1 {2} and 2 {3}, with potent antiulcer activity were isolated from cultures of Xenorhabdus spp. Both compounds exhibit antibacterial activity and potent antiulcer activity against stress-induced ulcers when dosed orally. In addition, 2 has antifungal activity. Their chemical structures were determined by extensive 1H-nmr, 13C-nmr, and mass spectral studies to be 3,4-dihydro-8-hydroxy-1H-2-benzopyran-1-one derivatives.

Original languageEnglish
Pages (from-to)785-795
Number of pages11
JournalJournal of Natural Products
Issue number3
Publication statusPublished - 1991
Externally publishedYes

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