Biologically Active Metabolites from Xenorhabdus Spp., Part 2. Benzopyran-1-one Derivatives with Gastroprotective Activity

Bernie V. McInerney; Walter C. Taylor; Micheal J. Lacey; Raymond J. Akhurst; Richard P. Gregson

doi:10.1021/np50075a006

Biologically Active Metabolites from Xenorhabdus Spp., Part 2. Benzopyran-1-one Derivatives with Gastroprotective Activity

Bernie V. McInerney
, Walter C. Taylor
, Micheal J. Lacey
, Raymond J. Akhurst
, Richard P. Gregson

Research output: Contribution to journal › Article › peer-review

188 Citations (Scopus)

Abstract

Two novel antibiotic compounds, named xenocoumacins 1 {2} and 2 {3}, with potent antiulcer activity were isolated from cultures of Xenorhabdus spp. Both compounds exhibit antibacterial activity and potent antiulcer activity against stress-induced ulcers when dosed orally. In addition, 2 has antifungal activity. Their chemical structures were determined by extensive ¹H-nmr, ¹³C-nmr, and mass spectral studies to be 3,4-dihydro-8-hydroxy-1H-2-benzopyran-1-one derivatives.

Original language	English
Pages (from-to)	785-795
Number of pages	11
Journal	Journal of Natural Products
Volume	54
Issue number	3
DOIs	https://doi.org/10.1021/np50075a006
Publication status	Published - 1991
Externally published	Yes

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title = "Biologically Active Metabolites from Xenorhabdus Spp., Part 2. Benzopyran-1-one Derivatives with Gastroprotective Activity",

abstract = "Two novel antibiotic compounds, named xenocoumacins 1 \{2\} and 2 \{3\}, with potent antiulcer activity were isolated from cultures of Xenorhabdus spp. Both compounds exhibit antibacterial activity and potent antiulcer activity against stress-induced ulcers when dosed orally. In addition, 2 has antifungal activity. Their chemical structures were determined by extensive 1H-nmr, 13C-nmr, and mass spectral studies to be 3,4-dihydro-8-hydroxy-1H-2-benzopyran-1-one derivatives.",

author = "McInerney, \{Bernie V.\} and Taylor, \{Walter C.\} and Lacey, \{Micheal J.\} and Akhurst, \{Raymond J.\} and Gregson, \{Richard P.\}",

year = "1991",

doi = "10.1021/np50075a006",

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AU - McInerney, Bernie V.

AU - Taylor, Walter C.

AU - Lacey, Micheal J.

AU - Akhurst, Raymond J.

AU - Gregson, Richard P.

PY - 1991

Y1 - 1991

N2 - Two novel antibiotic compounds, named xenocoumacins 1 {2} and 2 {3}, with potent antiulcer activity were isolated from cultures of Xenorhabdus spp. Both compounds exhibit antibacterial activity and potent antiulcer activity against stress-induced ulcers when dosed orally. In addition, 2 has antifungal activity. Their chemical structures were determined by extensive 1H-nmr, 13C-nmr, and mass spectral studies to be 3,4-dihydro-8-hydroxy-1H-2-benzopyran-1-one derivatives.

AB - Two novel antibiotic compounds, named xenocoumacins 1 {2} and 2 {3}, with potent antiulcer activity were isolated from cultures of Xenorhabdus spp. Both compounds exhibit antibacterial activity and potent antiulcer activity against stress-induced ulcers when dosed orally. In addition, 2 has antifungal activity. Their chemical structures were determined by extensive 1H-nmr, 13C-nmr, and mass spectral studies to be 3,4-dihydro-8-hydroxy-1H-2-benzopyran-1-one derivatives.

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ER -

Biologically Active Metabolites from Xenorhabdus Spp., Part 2. Benzopyran-1-one Derivatives with Gastroprotective Activity

Abstract

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