Biology of melanocytes and primary melanoma

M. Raza Zaidi; David E. Fisher; Helen Rizos

doi:10.1007/978-3-030-05070-2_42

Biology of melanocytes and primary melanoma

M. Raza Zaidi^*, David E. Fisher, Helen Rizos

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

21 Citations (Scopus)

Abstract

Melanocytes make up only a tiny proportion of the skin cellular milieu but have a major impact on skin appearance as well as skin cancer risk by modulating skin pigmentation. Cutaneous melanocytes are derived from precursor cells called melanoblasts that originate from the neural crest of the developing embryo and migrate for long distances to their niches in the epidermis and hair follicles, where theydifferentiate into melanin pigment-producing mini-factories. Melanin is synthesized and packaged within melanosomes, which are lysosome-related organelles responsible for melanin trafficking through dendrites to interacting keratinocytes. Melanocyte development, migration, proliferation, and differentiation are regulated by a complex network of extrinsic and intrinsic signaling pathways, which are responsive to key signals, such as ultraviolet radiation that stimulates melanin production (tanning). Alterations in components of these pathways may lead to melanomagenesis. Here we present an overview of the genes and pathways that regulate different aspects of the biology of melanocytes as well as their transformation to melanoma.

Original language	English
Title of host publication	Cutaneous melanoma
Editors	Charles M. Balch, Michael B. Atkins, Claus Garbe, Jeffrey E. Gershenwald, Allan C. Halpern, John M. Kirkwood, Grant A. McArthur, John F. Thompson, Arthur J. Sober
Place of Publication	Switzerland
Publisher	Springer, Springer Nature
Pages	3-40
Number of pages	38
Volume	1
Edition	Sixth
ISBN (Electronic)	9783030050702
ISBN (Print)	9783030050689
DOIs	https://doi.org/10.1007/978-3-030-05070-2_42
Publication status	Published - 2020

Keywords

Development of melanoblasts
Differentiation of melanocytes
From melanocyte to melanoma: a multistep process
Melanoma and the environment
Melanoma: a consequence of homeostatic disruption
Melanoma: cell of origin
Melanomagenesis
Molecular genetics: early lessons from familial and sporadic melanoma
Photobiology and melanoma
Regulation of differentiation
Regulation of migration
Regulation of specification
Regulation of survival
Regulation of survival and proliferation
Sun exposure and epidemiology

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10.1007/978-3-030-05070-2_42

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Zaidi, M. Raza ; Fisher, David E. ; Rizos, Helen. / Biology of melanocytes and primary melanoma. Cutaneous melanoma. editor / Charles M. Balch ; Michael B. Atkins ; Claus Garbe ; Jeffrey E. Gershenwald ; Allan C. Halpern ; John M. Kirkwood ; Grant A. McArthur ; John F. Thompson ; Arthur J. Sober. Vol. 1 Sixth. ed. Switzerland : Springer, Springer Nature, 2020. pp. 3-40

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title = "Biology of melanocytes and primary melanoma",

abstract = "Melanocytes make up only a tiny proportion of the skin cellular milieu but have a major impact on skin appearance as well as skin cancer risk by modulating skin pigmentation. Cutaneous melanocytes are derived from precursor cells called melanoblasts that originate from the neural crest of the developing embryo and migrate for long distances to their niches in the epidermis and hair follicles, where theydifferentiate into melanin pigment-producing mini-factories. Melanin is synthesized and packaged within melanosomes, which are lysosome-related organelles responsible for melanin trafficking through dendrites to interacting keratinocytes. Melanocyte development, migration, proliferation, and differentiation are regulated by a complex network of extrinsic and intrinsic signaling pathways, which are responsive to key signals, such as ultraviolet radiation that stimulates melanin production (tanning). Alterations in components of these pathways may lead to melanomagenesis. Here we present an overview of the genes and pathways that regulate different aspects of the biology of melanocytes as well as their transformation to melanoma.",

keywords = "Development of melanoblasts, Differentiation of melanocytes, From melanocyte to melanoma: a multistep process, Melanoma and the environment, Melanoma: a consequence of homeostatic disruption, Melanoma: cell of origin, Melanomagenesis, Molecular genetics: early lessons from familial and sporadic melanoma, Photobiology and melanoma, Regulation of differentiation, Regulation of migration, Regulation of specification, Regulation of survival, Regulation of survival and proliferation, Sun exposure and epidemiology",

author = "Zaidi, \{M. Raza\} and Fisher, \{David E.\} and Helen Rizos",

year = "2020",

doi = "10.1007/978-3-030-05070-2\_42",

language = "English",

isbn = "9783030050689",

volume = "1",

pages = "3--40",

editor = "Balch, \{Charles M.\} and Atkins, \{Michael B.\} and Claus Garbe and Gershenwald, \{Jeffrey E.\} and Halpern, \{Allan C.\} and Kirkwood, \{John M.\} and McArthur, \{Grant A.\} and Thompson, \{John F.\} and Sober, \{Arthur J.\}",

booktitle = "Cutaneous melanoma",

publisher = "Springer, Springer Nature",

address = "United States",

edition = "Sixth",

}

Biology of melanocytes and primary melanoma. / Zaidi, M. Raza; Fisher, David E.; Rizos, Helen.
Cutaneous melanoma. ed. / Charles M. Balch; Michael B. Atkins; Claus Garbe; Jeffrey E. Gershenwald; Allan C. Halpern; John M. Kirkwood; Grant A. McArthur; John F. Thompson; Arthur J. Sober. Vol. 1 Sixth. ed. Switzerland: Springer, Springer Nature, 2020. p. 3-40.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

TY - CHAP

T1 - Biology of melanocytes and primary melanoma

AU - Zaidi, M. Raza

AU - Fisher, David E.

AU - Rizos, Helen

PY - 2020

Y1 - 2020

N2 - Melanocytes make up only a tiny proportion of the skin cellular milieu but have a major impact on skin appearance as well as skin cancer risk by modulating skin pigmentation. Cutaneous melanocytes are derived from precursor cells called melanoblasts that originate from the neural crest of the developing embryo and migrate for long distances to their niches in the epidermis and hair follicles, where theydifferentiate into melanin pigment-producing mini-factories. Melanin is synthesized and packaged within melanosomes, which are lysosome-related organelles responsible for melanin trafficking through dendrites to interacting keratinocytes. Melanocyte development, migration, proliferation, and differentiation are regulated by a complex network of extrinsic and intrinsic signaling pathways, which are responsive to key signals, such as ultraviolet radiation that stimulates melanin production (tanning). Alterations in components of these pathways may lead to melanomagenesis. Here we present an overview of the genes and pathways that regulate different aspects of the biology of melanocytes as well as their transformation to melanoma.

AB - Melanocytes make up only a tiny proportion of the skin cellular milieu but have a major impact on skin appearance as well as skin cancer risk by modulating skin pigmentation. Cutaneous melanocytes are derived from precursor cells called melanoblasts that originate from the neural crest of the developing embryo and migrate for long distances to their niches in the epidermis and hair follicles, where theydifferentiate into melanin pigment-producing mini-factories. Melanin is synthesized and packaged within melanosomes, which are lysosome-related organelles responsible for melanin trafficking through dendrites to interacting keratinocytes. Melanocyte development, migration, proliferation, and differentiation are regulated by a complex network of extrinsic and intrinsic signaling pathways, which are responsive to key signals, such as ultraviolet radiation that stimulates melanin production (tanning). Alterations in components of these pathways may lead to melanomagenesis. Here we present an overview of the genes and pathways that regulate different aspects of the biology of melanocytes as well as their transformation to melanoma.

KW - Development of melanoblasts

KW - Differentiation of melanocytes

KW - From melanocyte to melanoma: a multistep process

KW - Melanoma and the environment

KW - Melanoma: a consequence of homeostatic disruption

KW - Melanoma: cell of origin

KW - Melanomagenesis

KW - Molecular genetics: early lessons from familial and sporadic melanoma

KW - Photobiology and melanoma

KW - Regulation of differentiation

KW - Regulation of migration

KW - Regulation of specification

KW - Regulation of survival

KW - Regulation of survival and proliferation

KW - Sun exposure and epidemiology

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M3 - Chapter

AN - SCOPUS:85150537772

SN - 9783030050689

VL - 1

SP - 3

EP - 40

BT - Cutaneous melanoma

A2 - Balch, Charles M.

A2 - Atkins, Michael B.

A2 - Garbe, Claus

A2 - Gershenwald, Jeffrey E.

A2 - Halpern, Allan C.

A2 - Kirkwood, John M.

A2 - McArthur, Grant A.

A2 - Thompson, John F.

A2 - Sober, Arthur J.

PB - Springer, Springer Nature

CY - Switzerland

ER -

Biology of melanocytes and primary melanoma

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Keywords

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