Biomarkers of pituitary carcinomas

Aydin Sav*, Fabio Rotondo, Luis V. Syro, Antonio Di Ieva, Michael D. Cusimano, Kalman Kovacs

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Introduction: Pituitary carcinoma is a rare tumor originating from adenohypophyseal cells. Currently, diverse pathogenetic mechanisms, i.e. de novo versus malignant transformation from pituitary adenoma, remain obscure and require further investigation. During the last two decades, scientific research added new horizons not only in regards to general tumor concepts but also in next generation biomarker armamentarium that sheds light on alternate pathways in carcinogenesis. Areas covered: In this review, the impact of apoptotic and proliferative markers, angiogenesis, telomerase activity, H-ras, HIF-1, HER-2/neu, Rb gene, and microRNAs in pathogenetic mechanisms of pituitary carcinomas were revised. Expert commentary: It is becoming increasingly important for the need of standardization of new biomarkers but also for better comprehension of the diverse pathways in tumorigenesis. This can only be accomplished by tapping into the continuously expanding spectrum of new biomarkers.

Original languageEnglish
Pages (from-to)253-261
Number of pages9
JournalExpert Review of Endocrinology and Metabolism
Volume11
Issue number3
DOIs
Publication statusPublished - 3 May 2016

Keywords

  • Angiogenesis
  • Galectin-3
  • H-ras
  • HIF-1
  • Ki-67
  • microRNA
  • P27/KIP1
  • P53
  • pituitary carcinoma
  • telomerase

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