Biomarkers provide clues to early events in the pathogenesis of breast implant-associated anaplastic large cell lymphoma

Marshall E. Kadin*, Anand Deva, Haiying Xu, John Morgan, Pranay Khare, Roderick A F MacLeod, Bruce W. Van Natta, William P. Adams, Garry S. Brody, Alan L. Epstein

*Corresponding author for this work

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Almost 200 women worldwide have been diagnosed with breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). The unique location and specific lymphoma type strongly suggest an etio-pathologic link between breast implants and BIA-ALCL. It is postulated that chronic inflammation via bacterial infection may be an etiological factor. BIA-ALCL resembles primary cutaneous ALCL ( pcALCL) in morphology, activated T-cell phenotype, and indolent clinical course. Gene expression array analysis, flow cytometry, and immunohistochemistry were used to study pcALCL and BIA-ALCL cell lines. Clinical samples were also studied to characterize transcription factor and cytokine profiles of tumor cells and surrounding lymphocytes. BIA-ALCL and pcALCL were found to have common expression of transcription factors SOCS3, JunB, SATB1, and a cytokine profile suggestive of a Th1 phenotype. Similar patterns were observed in a CD30+ cutaneous lymphoproliferative disorder (LPD). The patterns of cytokine and transcription factor expression suggest that BIAALCL is likely to arise from chronic bacterial antigen stimulation of T-cells. Further analysis of cytokine and transcription factor profiles may allow early detection and treatment of BIA-ALCL leading to better prognosis and survival.

Original languageEnglish
Pages (from-to)773-781
Number of pages9
JournalAesthetic Surgery Journal
Volume36
Issue number7
DOIs
Publication statusPublished - 1 Jul 2016

Fingerprint Dive into the research topics of 'Biomarkers provide clues to early events in the pathogenesis of breast implant-associated anaplastic large cell lymphoma'. Together they form a unique fingerprint.

  • Cite this