Biomechanics and biocompatibility of the perfect conduit-can we build one?

Michael J. Byrom, Martin K C Ng, Paul G Bannon

Research output: Contribution to journalArticle


No currently available conduit meets the criteria for an ideal coronary artery bypass graft. The perfect conduit would combine the availability and complication-free harvest of a synthetic vessel with the long-term patency performance of the internal mammary artery. However, current polymer conduits suffer from inelastic mechanical properties and especially poor surface biocompatibility, resulting in early loss of patency as a coronary graft. Approaches to manufacture an improved conduit using new polymers or polymer surfaces, acellular matrices, or cellular constructs have to date failed to achieve a commercially successful alternative. Elastin, by mimicking the native extracellular environment as well as providing elasticity, provides the 'missing link' in vascular conduit design and brings new hope for realization of the perfect conduit.

Original languageEnglish
Pages (from-to)435-43
Number of pages9
JournalAnnals of Cardiothoracic Surgery
Issue number4
Publication statusPublished - Jul 2013
Externally publishedYes


  • Coronary artery bypass
  • blood vessel prosthesis
  • biocompatible materials
  • biomechanics

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