Biomedical applications and colloidal properties of amphiphilically modified chitosan hybrids

Mikael Larsson, Wei-Chen Huang, Meng-Hsuan Hsiao, Yen-Jen Wang, Magnus Nydén, Shih-Hwa Chiou, Dean-Mo Liu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

94 Citations (Scopus)


Chitosan is among the most abundant biopolymers on earth and has been either used or exhibited potential in a wide variety of industrial and biomedical applications. With the advancement of materials technologies, chitosan has been chemically modified to self-assemble into nanoarchitectures that are usable in advanced biomedical applications, such as drug nanocarriers, macroscopic injectables, tissue-engineering scaffolds, and nanoimaging agents. Colloidal amphiphilically modified chitosan (AMC) is a relatively recent material receiving increased attention with numerous publications addressing the medical advantages of specific systems. To date, many reviews have focused on the synthesis and biomedical properties of chitosan-based biomaterials, but a comprehensive study focusing on the colloidal properties of AMC in relation to biomedical performance appears to be lacking. This review provides a survey of the field, critically reviewing the colloidal properties and biomedical performance of AMC systems, such as nanoparticle drug delivery systems and macroscopic medical devices. Finally, the future development, market potential, and clinical implications of these promising colloidal-structured biomaterials are summarised.

Original languageEnglish
Pages (from-to)1307-1328
Number of pages22
JournalProgress in Polymer Science
Issue number9
Publication statusPublished - Sept 2013
Externally publishedYes


  • Amphiphilic modified chitosan
  • Colloidal properties
  • Biomedical applications


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