@inbook{0330d20d8aee4c6596c7ddba97c747f5,
title = "Biomedical Engineering Analysis of the Rupture Risk of Cerebral Aneurysms: Flow Comparison of Three Small Pre-ruptured Versus Six Large Unruptured Cases",
abstract = "A relationship between blood flows in cerebral aneurysms and their rupture remains obscure. In clinical practice, the size of aneurysms is one of the important factors for determining a strategy of treatment, but in our database three small aneurysms became ruptured during follow-up. Here, we aim to study their pre-ruptured hemodynamics, and differentiate them with those of six large unruptured aneurysms. All the aneurysms occurred in internal carotid artery, and their mean sizes were 6 and 10.8 mm for pre-ruptured and unruptured cases, respectively. We reproduced their replica as a patient-specific elastic model using clinical images obtained by digital subtraction angiography and a series of rapid prototyping techniques. Flows were reproduced in vitro using a cerebral flow simulator, and visualized by Time-resolved Particle Image Velocimetry. All pre-ruptured cases showed the collision of an incoming flow at a distal neck, and formed a prominent jet stream directing towards the aneurismal head. In contrast, none of unruptured aneurysms had such a marked impingement, and their flows were most likely characterized by swirling patterns. All unruptured cases occurred in a twisted vessel, or carotid siphon, whereas pre-ruptured ones were located downstream whose geometries consisted of a simple curvature. These findings suggest that internal carotid artery has a regional dependency of the risk of aneurismal rupture. Furthermore, the presence of jet streams for smallsized aneurysms may be a substantial indicator of the rupture and immediate treatments.",
keywords = "cerebral aneurysm, hemodynamics, PIV, rupture",
author = "A. Kamoda and T. Yagi and A. Sato and Y. Qian and K. Iwasaki and M. Umezu and T. Akutsu and H. Takao and Y. Murayama",
year = "2009",
doi = "10.1007/978-3-540-92841-6_397",
language = "English",
isbn = "9783540928409",
series = "IFMBE Proceedings",
publisher = "Springer, Springer Nature",
pages = "1600--1603",
editor = "Lim, {Chwee Teck} and Goh, {James C. H.}",
booktitle = "13th International Conference on Biomedical Engineering, ICBME 2008",
address = "United States",
note = "13th International Conference on Biomedical Engineering, ICBME 2008 ; Conference date: 03-12-2008 Through 06-12-2008",
}