Biomedical Engineering Analysis of the Rupture Risk of Cerebral Aneurysms: Flow Comparison of Three Small Pre-ruptured Versus Six Large Unruptured Cases

A. Kamoda, T. Yagi, A. Sato, Y. Qian, K. Iwasaki, M. Umezu, T. Akutsu, H. Takao, Y. Murayama

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Citations (Scopus)

Abstract

A relationship between blood flows in cerebral aneurysms and their rupture remains obscure. In clinical practice, the size of aneurysms is one of the important factors for determining a strategy of treatment, but in our database three small aneurysms became ruptured during follow-up. Here, we aim to study their pre-ruptured hemodynamics, and differentiate them with those of six large unruptured aneurysms. All the aneurysms occurred in internal carotid artery, and their mean sizes were 6 and 10.8 mm for pre-ruptured and unruptured cases, respectively. We reproduced their replica as a patient-specific elastic model using clinical images obtained by digital subtraction angiography and a series of rapid prototyping techniques. Flows were reproduced in vitro using a cerebral flow simulator, and visualized by Time-resolved Particle Image Velocimetry. All pre-ruptured cases showed the collision of an incoming flow at a distal neck, and formed a prominent jet stream directing towards the aneurismal head. In contrast, none of unruptured aneurysms had such a marked impingement, and their flows were most likely characterized by swirling patterns. All unruptured cases occurred in a twisted vessel, or carotid siphon, whereas pre-ruptured ones were located downstream whose geometries consisted of a simple curvature. These findings suggest that internal carotid artery has a regional dependency of the risk of aneurismal rupture. Furthermore, the presence of jet streams for smallsized aneurysms may be a substantial indicator of the rupture and immediate treatments.

Original languageEnglish
Title of host publication13th International Conference on Biomedical Engineering, ICBME 2008
EditorsChwee Teck Lim, James C. H. Goh
Place of PublicationHeidelberg
PublisherSpringer, Springer Nature
Pages1600-1603
Number of pages4
ISBN (Electronic)9783540928416
ISBN (Print)9783540928409
DOIs
Publication statusPublished - 2009
Externally publishedYes
Event13th International Conference on Biomedical Engineering, ICBME 2008 - , Singapore
Duration: 3 Dec 20086 Dec 2008

Publication series

NameIFMBE Proceedings
PublisherSpringer, Berlin, Heidelberg
Volume23
ISSN (Print)1680-0737

Other

Other13th International Conference on Biomedical Engineering, ICBME 2008
CountrySingapore
Period3/12/086/12/08

Keywords

  • cerebral aneurysm
  • hemodynamics
  • PIV
  • rupture

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