Biosynthesis of isocyanoterpenes in sponges

Peter Karuso, Paul J. Scheuer*

*Corresponding author for this work

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

A marine sponge from Hawaii, Ciocalypta sp., incorporated [14C]cyanide (1.8%) into 2-isocyanopupukeanane (8). Doubly labeled [13C,15N]cyanide was incorporated intact (1.46%) into 9-isocyanoneopupukeanane (10). Another sponge, Acanthella sp., from Guam incorporated [14C]cyanide (1.5%) into kalihinol-F (11). Labeled 11 was transformed into the corresponding triamine and hence the trisbenzylurea, which after purification was devoid of radioactivity, thereby proving that cyanide serves as specific precursor for the isocyano function.

Original languageEnglish
Pages (from-to)2092-2095
Number of pages4
JournalJournal of Organic Chemistry
Volume54
Issue number9
Publication statusPublished - 1989
Externally publishedYes

Fingerprint Dive into the research topics of 'Biosynthesis of isocyanoterpenes in sponges'. Together they form a unique fingerprint.

  • Cite this