Microbial-derived products, while do not have many environmental side effects of their synthetic counterparts, have proved more efficient than those synthetically obtained. The nature has provided a treasure of microorganisms with capabilities to produce vast variety of novel compounds. This ability has been arised during long last of evolution and adaptation to diverse chemical and physical microenviroments. Microbial-derived metabolites have made their own space in industries and therefore human life. Among these microorganisms, halophilic and halotolerant actinobacteria are recently gaining much attentions. Metabolites and biological functions from halophilic or halotolerant members of this phylum of bacteria may resolving the ever-increasing thirst of industry for metabolites with salttolerancy to cope a range of issues from environmental pollution to diseases and world's hunger. In the current chapter, it has been tried to introduce the less dealt group of halophilic and halotolerant actinobacteria, and shed light on their potential to be exploited in various industry sectors.