Biotechnologies toward mitigating, curing, and ultimately preventing edema through compression therapy

Daniel J. Hageman, Shuying Wu, Sharon Kilbreath, Stanley G. Rockson, Chun Wang, Melissa L. Knothe Tate*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)


For a century-old problem, edema and its treatment have gone remarkably unnoticed by the biomedical community. Given the prevalence of lymphedema and its debilitating repercussions, there is an acute need for both efficacy-based measures and clinical standards to guide compression garment design and therapeutic application. This review outlines the current state of the art in compression treatment and suggests an integrated biomedical engineering approach going forward. Characterizing the pressure gradient profiles of commercial compression sleeves is necessary to better understand the role of compression treatment in the mitigation of swelling. Integration of pressure sensor technologies with advanced materials design and manufacture provides a critical path not only to elucidate the mechanisms of but also to improve on current compression-based therapies and associated therapeutic devices.

Original languageEnglish
Pages (from-to)537-548
Number of pages12
JournalTrends in Biotechnology
Issue number5
Publication statusPublished - May 2018
Externally publishedYes


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