The health benefits of fruits have been exploited since ancient days. A healthy diet not only keeps away various chronic diseases and metabolic syndromes but also confers protection from the undesirable side effects of drugs. Habitual consumption of phytonutrient rich fruits and vegetables is a potential strategy for the prevention or delay of various diseases. Berry fruits are rich in vitamins and antioxidant polyphenolics. Blueberries, in particular, are a rich source of antioxidant flavonoids, dietary fiber, trace elements, and vitamins. Their vast health-promoting potential includes cardio-, neuro-, hepato-, and immuno-protection, making them a preferable dietary interventional choice. Moreover, research has reported that blueberry supplementation improved ocular health,offset macular degeneration, and reduced urinary tract infection. The health benefits and nutrient content in this superfruit is summarized in this chapter.