Blunted adenosine A2a receptor function in platelets in patients with major depression

M. Berk, H. Plein, D. Ferreira, B. Jersky

    Research output: Contribution to journalArticle

    22 Citations (Scopus)

    Abstract

    There is provisional evidence of involvement of adenosine in depression. In this study, the second messenger intracellular calcium response in platelets was measured in patients with major depression and controls using spectrofluorometry. The primary result of this study was a statistically significantly blunted second messenger response to agonist stimulation in the depressed group compared to the control group at the 50 and 100 nM and 1 μM dosage levels. This suggests that dysregulation of the adenosine A2a receptor may be present in depression.

    Original languageEnglish
    Pages (from-to)183-186
    Number of pages4
    JournalEuropean Neuropsychopharmacology
    Volume11
    Issue number2
    DOIs
    Publication statusPublished - 2001

    Keywords

    • Adenosine
    • Adenosine A2a receptor
    • Calcium
    • Depression
    • Intracellular signalling
    • Mood

    Fingerprint Dive into the research topics of 'Blunted adenosine A2a receptor function in platelets in patients with major depression'. Together they form a unique fingerprint.

  • Cite this