Body mass index delineates ALS from FTD

implications for metabolic health

R. M. Ahmed*, E. Mioshi, J. Caga, M. Shibata, M. Zoing, L. Bartley, O. Piguet, J. R. Hodges, M. C. Kiernan

*Corresponding author for this work

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Weight loss and catabolic changes are increasingly recognized as factors that influence outcomes in patients with amyotrophic lateral sclerosis (ALS). An association between disease progression and low BMI has been reported in ALS; however, it remains unknown whether low BMI occurs across all forms of ALS and whether BMI changes with the development of cognitive impairment across the spectrum between ALS and frontotemporal dementia (FTD). One hundred and three ALS patients (56 limb predominant, 18 bulbar predominant, 13 ALS plus, 16 ALSFTD) were recruited and compared to 19 behavioral variant FTD (bvFTD) patients and a group of age-matched healthy controls. BMI was measured at the initial clinical visit. Patients were characterized as underweight, normal, overweight or obese, based on the current World Health Organization (WHO) guidelines. Limb and bulbar ALS patients had significantly lower BMI than ALS plus, ALSFTD, and bvFTD patient groups. When BMI was categorized using WHO guidelines the majority of the limb and bulbar ALS patients were either underweight or normal weight, whilst the majority of the ALS plus, ALSFTD and bvFTD patients were either overweight or obese. On follow-up BMI assessment the limb and bulbar groups tended to decline whilst ALS plus, ALSFTD and bvFTD groups remained stable or increased. BMI is significantly higher in ALS individuals with cognitive deficits. The present findings have prognostic implications for disease progression and may help delineate the metabolic profile across the ALSFTD spectrum.

Original languageEnglish
Pages (from-to)1774-1780
Number of pages7
JournalJournal of Neurology
Volume261
Issue number9
DOIs
Publication statusPublished - 2014
Externally publishedYes

    Fingerprint

Keywords

  • Amyotrophic lateral sclerosis
  • Body mass index
  • Frontotemporal dementia
  • Metabolism

Cite this

Ahmed, R. M., Mioshi, E., Caga, J., Shibata, M., Zoing, M., Bartley, L., ... Kiernan, M. C. (2014). Body mass index delineates ALS from FTD: implications for metabolic health. Journal of Neurology, 261(9), 1774-1780. https://doi.org/10.1007/s00415-014-7416-6