Bone remodeling during pregnancy and post-partum assessed by metal lead levels and isotopic concentrations

Brian Gulson*, Alan Taylor, John Eisman

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    27 Citations (Scopus)

    Abstract

    Bone remodeling is normally evaluated using bone turnover markers/indices as indicators of bone resorption and formation. However, during pregnancy and post-partum, there have been inconsistent results between and within biomarkers for bone formation and resorption. These differences may relate to pregnancy-related changes in metabolism and/or hemodilution altering measured marker levels. An alternative approach to evaluating bone remodeling is to use the metal lead (Pb) concentrations and Pb isotopic compositions in blood. These measurements can also provide information on the amount of Pb that is mobilized from the maternal skeleton. Despite some similarities with accepted bone turnover markers, the Pb data demonstrate increased bone resorption throughout pregnancy that further continues post-partum independent of length of breast-feeding, dietary intake and resumption of menses. Furthermore the isotopic measurements are not affected by hemodilution. These data confirm calcium balance studies that indicate increased bone resorption throughout pregnancy and lactation. They also indicate potentially major public health implications of the transfer of maternal Pb burden to the fetus and new born.

    Original languageEnglish
    Pages (from-to)40-51
    Number of pages12
    JournalBone
    Volume89
    DOIs
    Publication statusPublished - 1 Aug 2016

    Keywords

    • Bone
    • Epigenetics
    • Fetal exposure
    • Lead
    • Lead isotopic
    • Markers
    • Remodeling

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