Brevianamides with antitubercular potential from a marine-derived isolate of aspergillus versicolor

Fuhang Song, Xinru Liu, Hui Guo, Biao Ren, Caixia Chen, Andrew M. Piggott, Ke Yu, Hong Gao, Qian Wang, Mei Liu, Xueting Liu, Huanqin Dai, Lixin Zhang*, Robert J. Capon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

73 Citations (Scopus)

Abstract

An Aspergillus versicolor isolated from sediment collected from the Bohai Sea, China, yielded the new dimeric diketopiperazine brevianamide S (1), together with three new monomeric cometabolites, brevianamides T (2), U (3), and V (4). Structures were determined by detailed spectroscopic analysis. Brevianamide S exhibited selective antibacterial activity against Bacille Calmette-Guérin (BCG), suggestive of a new mechanism of action that could inform the development of next-generation antitubercular drugs.

Original languageEnglish
Pages (from-to)4770-4773
Number of pages4
JournalOrganic Letters
Volume14
Issue number18
DOIs
Publication statusPublished - 21 Sep 2012
Externally publishedYes

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