Brevianamides with antitubercular potential from a marine-derived isolate of aspergillus versicolor

Fuhang Song; Xinru Liu; Hui Guo; Biao Ren; Caixia Chen; Andrew M. Piggott; Ke Yu; Hong Gao; Qian Wang; Mei Liu; Xueting Liu; Huanqin Dai; Lixin Zhang; Robert J. Capon

doi:10.1021/ol302051x

Brevianamides with antitubercular potential from a marine-derived isolate of aspergillus versicolor

Fuhang Song, Xinru Liu, Hui Guo, Biao Ren, Caixia Chen, Andrew M. Piggott, Ke Yu, Hong Gao, Qian Wang, Mei Liu, Xueting Liu, Huanqin Dai, Lixin Zhang^*, Robert J. Capon

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

103 Citations (Scopus)

Abstract

An Aspergillus versicolor isolated from sediment collected from the Bohai Sea, China, yielded the new dimeric diketopiperazine brevianamide S (1), together with three new monomeric cometabolites, brevianamides T (2), U (3), and V (4). Structures were determined by detailed spectroscopic analysis. Brevianamide S exhibited selective antibacterial activity against Bacille Calmette-Guérin (BCG), suggestive of a new mechanism of action that could inform the development of next-generation antitubercular drugs.

Original language	English
Pages (from-to)	4770-4773
Number of pages	4
Journal	Organic Letters
Volume	14
Issue number	18
DOIs	https://doi.org/10.1021/ol302051x
Publication status	Published - 21 Sep 2012
Externally published	Yes

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title = "Brevianamides with antitubercular potential from a marine-derived isolate of aspergillus versicolor",

abstract = "An Aspergillus versicolor isolated from sediment collected from the Bohai Sea, China, yielded the new dimeric diketopiperazine brevianamide S (1), together with three new monomeric cometabolites, brevianamides T (2), U (3), and V (4). Structures were determined by detailed spectroscopic analysis. Brevianamide S exhibited selective antibacterial activity against Bacille Calmette-Gu{\'e}rin (BCG), suggestive of a new mechanism of action that could inform the development of next-generation antitubercular drugs.",

author = "Fuhang Song and Xinru Liu and Hui Guo and Biao Ren and Caixia Chen and Piggott, {Andrew M.} and Ke Yu and Hong Gao and Qian Wang and Mei Liu and Xueting Liu and Huanqin Dai and Lixin Zhang and Capon, {Robert J.}",

year = "2012",

month = sep,

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T1 - Brevianamides with antitubercular potential from a marine-derived isolate of aspergillus versicolor

AU - Song, Fuhang

AU - Liu, Xinru

AU - Guo, Hui

AU - Ren, Biao

AU - Chen, Caixia

AU - Piggott, Andrew M.

AU - Yu, Ke

AU - Gao, Hong

AU - Wang, Qian

AU - Liu, Mei

AU - Liu, Xueting

AU - Dai, Huanqin

AU - Zhang, Lixin

AU - Capon, Robert J.

PY - 2012/9/21

Y1 - 2012/9/21

N2 - An Aspergillus versicolor isolated from sediment collected from the Bohai Sea, China, yielded the new dimeric diketopiperazine brevianamide S (1), together with three new monomeric cometabolites, brevianamides T (2), U (3), and V (4). Structures were determined by detailed spectroscopic analysis. Brevianamide S exhibited selective antibacterial activity against Bacille Calmette-Guérin (BCG), suggestive of a new mechanism of action that could inform the development of next-generation antitubercular drugs.

AB - An Aspergillus versicolor isolated from sediment collected from the Bohai Sea, China, yielded the new dimeric diketopiperazine brevianamide S (1), together with three new monomeric cometabolites, brevianamides T (2), U (3), and V (4). Structures were determined by detailed spectroscopic analysis. Brevianamide S exhibited selective antibacterial activity against Bacille Calmette-Guérin (BCG), suggestive of a new mechanism of action that could inform the development of next-generation antitubercular drugs.

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JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 18

ER -

Brevianamides with antitubercular potential from a marine-derived isolate of aspergillus versicolor

Abstract

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