Bridging the gap between design and reality

A dual evolutionary strategy for the design of synthetic genetic circuits

J. S. Hallinan*, S. Park, A. Wipat

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contribution

3 Citations (Scopus)

Abstract

Computational design is essential to the field of synthetic biology, particularly as its practitioners become more ambitious, and system designs become larger and more complex. However, computational models derived from abstract designs are unlikely to behave in the same way as organisms engineered from those same designs. We propose an automated, iterative strategy involving evolution both in silico and in vivo, with feedback between strands as necessary, combined with automated reasoning. This system can help bridge the gap between the behaviour of computational models and that of engineered organisms in as rapid and cost-effective a manner as possible.

Original languageEnglish
Title of host publicationBIOINFORMATICS 2012 - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms
EditorsJan Schier, Carlos Correia, Ana Fred, Hugo Gamboa
Place of PublicationPortugal
PublisherSciTePress
Pages263-268
Number of pages6
ISBN (Print)9789898425904
DOIs
Publication statusPublished - 2012
Externally publishedYes
EventInternational Conference on Bioinformatics Models, Methods and Algorithms, BIOINFORMATICS 2012 - Vilamoura, Algarve, Portugal
Duration: 1 Feb 20124 Feb 2012

Other

OtherInternational Conference on Bioinformatics Models, Methods and Algorithms, BIOINFORMATICS 2012
CountryPortugal
CityVilamoura, Algarve
Period1/02/124/02/12

Fingerprint Dive into the research topics of 'Bridging the gap between design and reality: A dual evolutionary strategy for the design of synthetic genetic circuits'. Together they form a unique fingerprint.

  • Cite this

    Hallinan, J. S., Park, S., & Wipat, A. (2012). Bridging the gap between design and reality: A dual evolutionary strategy for the design of synthetic genetic circuits. In J. Schier, C. Correia, A. Fred, & H. Gamboa (Eds.), BIOINFORMATICS 2012 - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms (pp. 263-268). Portugal: SciTePress. https://doi.org/10.5220/0003887002630268